2012
DOI: 10.1002/wmts.58
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P2X receptors in the cardiovascular system

Abstract: P2X receptors are ligand‐gated ion channels activated by ATP. They are trimeric receptors formed from P2X subunit proteins (P2X1–7), which can associate as homomers or heteromers. Among the P2X receptors, the P2X1 receptor is most widely distributed in the cardiovascular system, being expressed on the smooth muscle of most blood vessels investigated. It mediates contraction to ATP coreleased with noradrenaline as a sympathetic neurotransmitter. P2X receptors are also expressed in the heart and mediate an incre… Show more

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Cited by 11 publications
(8 citation statements)
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References 127 publications
(170 reference statements)
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“…P2X receptors subunits can combine to form functional homomeric and heteromeric ion channels which have distinctive pharmacological and biophysical properties [23,33]. Immunoreactivity to P2X1, P2X2 and P2X4 receptor subunits has been reported in the mammalian vasculature, with homomeric P2X1 receptors likely to be the major contributor to ATP-mediated responses [28]. However, knowledge regarding the properties and contribution of P2X receptors in human blood vessels is limited.…”
Section: Introductionmentioning
confidence: 99%
“…P2X receptors subunits can combine to form functional homomeric and heteromeric ion channels which have distinctive pharmacological and biophysical properties [23,33]. Immunoreactivity to P2X1, P2X2 and P2X4 receptor subunits has been reported in the mammalian vasculature, with homomeric P2X1 receptors likely to be the major contributor to ATP-mediated responses [28]. However, knowledge regarding the properties and contribution of P2X receptors in human blood vessels is limited.…”
Section: Introductionmentioning
confidence: 99%
“…Among the other P2 receptor subtypes likely to play a role in acute inflammation, the P2X 1 receptor deserves attention because it is expressed on numerous cell types involved in inflammation, such as neutrophils, macrophages, platelets, and vascular smooth muscle cells, but it appears to be absent from vascular endothelial cells (23)(24)(25)(26). Notably, it was reported recently that the P2X 1 receptor facilitates W-peptide-induced neutrophil chemotaxis in Boyden chamber assays (27).…”
mentioning
confidence: 99%
“…Functional and physical interactions of Panx1 with P2X 7 receptor bound to CPB would influence Panx1 channels opening promoting ATP release [ 68 ]. Both enterocytes and endothelial cells express the P2X 7 receptor and Panx1 [ 70 , 71 ], but their role in CPB-associated disease in vivo needs further investigation.…”
Section: C Perfringens Beta Toxin (Cpb)mentioning
confidence: 99%