P2X4 receptor as a modulator in the function of P2X receptor in CD4+ T cells from peripheral blood and adipose tissue

Ruiz-Rodríguez, Victor Manuel; Cortés-García, Juan D.; Briones-Espinoza, Margarita de Jesús; Rodríguez-Varela, Eduardo; Vega-Cárdenas, Mariela; Gómez-Otero, Arturo; García-Hernández, Mariana Haydee; Portales-Pérez, Diana Patricia

doi:10.1016/j.molimm.2019.06.009

Cited by 18 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results confirm the previously reported relationship between obesity and BRCA, demonstrating the involvement of adipose tissue and the promotion of BRCA metastasis (Sabol et al, 2019). In this sense, we previously reported that purinergic signaling in adipose tissue and peripheral blood participates in generalized low-grade inflammation during overweight or obesity (Ruiz-Rodriguez et al, 2019). Furthermore, BRCA patients with T2DM showed no alteration in the P2X7 expression, which is consistent with previously reported showing that the expression and function of P2X7 on CD8 + T cells is not modified in patients with T2DM (Garcia-Hernandez et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

Chemoresistance in Breast Cancer Patients Associated With Changes in P2X7 and A2A Purinergic Receptors in CD8+ T Lymphocytes

et al. 2020

Self Cite

View full text Add to dashboard Cite

Breast cancer (BRCA) is the most frequent cancer type that afflicts women. Unfortunately, despite all the current therapeutic strategies, many patients develop chemoresistance hampering the efficacy of treatment. Hence, an early indicator of therapy efficacy might aid in the search for better treatment and patient survival. Although emerging evidence indicates a key role of the purinergic receptors P2X7 and A2A in cancer, less is known about their involvement in BRCA chemoresistance. In this sense, as the chemotherapeutic treatment stimulates immune system response, we evaluated the expression and function of P2X7 and A2A receptors in CD8+ T cells before and four months after BRCA patients received neoadjuvant chemotherapy. The results showed an increase in the levels of expression of P2X7 and a decrease in the expression of A2A in CD8+ T cells in non-chemoresistant (N-CHR) patients, compared to chemoresistant (CHR) patients. Interestingly, in CHR patients, reduced expression of P2X7 occurs along with a decrease in the CD62L shedding and the production of IFN-γ. In the case of the A2A function, the inhibition of IFN-γ production was not observed after chemotherapy in CHR patients. A possible relationship between the modulation of the expression and function of the P2X7 and A2A receptors was found, according to the molecular subtypes, where the patients that were triple-negative and human epidermal growth factor receptor 2 (HER2)-enriched presented more alterations. Comorbidities such as overweight/obesity and type 2 diabetes mellitus (T2DM) participate in the abnormalities detected. Our results demonstrate the importance of purinergic signaling in CD8+ T cells during chemoresistance, and it could be considered to implement personalized therapeutic strategies.

show abstract

Section: Discussionsupporting

confidence: 92%

Chemoresistance in Breast Cancer Patients Associated With Changes in P2X7 and A2A Purinergic Receptors in CD8+ T Lymphocytes

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…shows that an increase in P2XR receptor expression could be associated with a progression in the metabolic state and the progression in the metabolic state is associated with an increase in BMI [24]. Rather than looking at one time point, our study focused on BMI status transition.…”

Section: Discussionmentioning

confidence: 99%

Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

et al. 2021

View full text Add to dashboard Cite

Background Previous studies have shown that DNA methylation (DNAm) is associated with body mass index (BMI). However, it is unknown whether DNAm at pre-adolescence is associated with BMI status transition from pre- to post-adolescence. In the Isle of Wight (IoW) birth cohort, genome-wide DNA methylation in whole blood was measured using Illumina Infinium Human450 and EPIC BeadChip arrays in n = 325 subjects, and pre- to post-adolescence BMI transition was classified into four groups: (1) normal to normal, (2) normal to overweight or obese, (3) overweight or obese to normal, and (4) persistent overweight or obese. We used recursive random forest to screen genome-wide Cytosine-phosphate-Guanine (CpG) sites with DNAm potentially associated with BMI transition for each gender, and the association of BMI status transition with DNAm at an earlier age was assessed via logistic regressions. To evaluate gender specificity, interactions between DNAm and gender were included in the model. Findings in the IoW cohort were further tested in an independent cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Results In total, 174 candidate CpGs were selected including CpGs from screening and CpGs previously associated correctionally with BMI in children and adults. Of these 174 CpGs, pre-adolescent DNAm of 38 CpGs in the IoW cohort was associated with BMI status transition, including 30 CpGs showing gender-specific associations. Thirteen CpGs showed consistent associations between the IoW cohort and the ALSPAC cohort (11 of which were gender-specific). Conclusion Pre-adolescence DNAm is associated with the change in BMI status from pre- to post-adolescence and such associations are likely to be gender-specific.

show abstract

“…Among P2XR subtypes (P2X1-7), the critical role of P2X1, P2X4, and P2X7 receptors (P2X1R, P2X4R, and P2X7R) in inflammatory conditions has been well identified [ 21 , 56 ]. T lymphocyte activation is linked to P2X1R due to its role in the entrance of calcium into the cell [ 57 ]. Data have shown the wide distribution of P2X4R in the brain, spinal cord, ganglia, liver, kidney, and lung [ 58 , 59 ].…”

Section: Purinoceptors Role In Inflammatory Conditionsmentioning

confidence: 99%

“…Data have shown the wide distribution of P2X4R in the brain, spinal cord, ganglia, liver, kidney, and lung [ 58 , 59 ]. Furthermore, P2X4R is expressed at high levels of mRNA in immune cells [ 57 ]. Besides, P2X4R fast trafficking to the macrophages in response to inflammatory provocations [ 60 ] and augmentation of bacterial killing ability of these cells have been indicated [ 61 ].…”

Section: Purinoceptors Role In Inflammatory Conditionsmentioning

confidence: 99%

Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19

Zarei

Vaighan

Ziai

2021

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

The coronavirus disease-19 (COVID-19), at first, was reported in Wuhan, China, and then rapidly became pandemic throughout the world. Cytokine storm syndrome (CSS) in COVID-19 patients is associated with high levels of cytokines and chemokines that cause multiple organ failure, systemic inflammation, and hemodynamic instabilities. Acute respiratory distress syndrome (ARDS), a common complication of COVID-19, is a consequence of cytokine storm. In this regard, several drugs have been being investigated to suppress this inflammatory condition. Purinergic signaling receptors comprising of P1 adenosine and P2 purinoceptors play a critical role in inflammation. Therefore, activation or inhibition of some subtypes of these kinds of receptors is most likely to be beneficial to attenuate cytokine storm. This article summarizes suggested therapeutic drugs with potential anti-inflammatory effects through purinergic receptors.

show abstract

P2X4 receptor as a modulator in the function of P2X receptor in CD4+ T cells from peripheral blood and adipose tissue

Cited by 18 publications

References 37 publications

Chemoresistance in Breast Cancer Patients Associated With Changes in P2X7 and A2A Purinergic Receptors in CD8+ T Lymphocytes

Chemoresistance in Breast Cancer Patients Associated With Changes in P2X7 and A2A Purinergic Receptors in CD8+ T Lymphocytes

Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19

Contact Info

Product

Resources

About