P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy

Sarti, Alba Clara; Vultaggio-Poma, Valentina; Virgilio, Francesco Di

doi:10.1007/s11302-021-09783-w

Cited by 5 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the purinergic system, growing evidence supported that purinergic P2X7Rs play important role in different cancers, including lung cancer, colorectal cancer, breast cancer, and acute myeloid leukemia [12][13][14][15][16][17][18][19]. Apart from the strategy targeting the P2X7 ion channel, from antibodies and nanobodies to small-molecule drugs, which has been proved to improve the outcomes in models of cancer [20][21][22][23][24], the nature product is also taken into account for the development of potential anti-cancer drug to target purinergic receptors [25,26]. Atractylenolide I (Atr-I, Fig.…”

Section: Introductionmentioning

confidence: 99%

P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells

Han

Bai

et al. 2022

Purinergic Signalling

View full text Add to dashboard Cite

Atractylenolide I (Atr-I) was found to sensitize a variety of human cancer cells in previous studies. Purinergic P2X7R plays important role in different cancers. However, whether Atr-I could generate antitumor activity in human cervical cancer cells and P2X7R get involved in this effect remain unclear. In this study, Hela (HPV 18 +) and SiHa (HPV 16 +) cells were treated with different doses of Atr-I. The results indicated that agonist and antagonist of P2X7 receptors, BzATP and JNJ-47965567 (JNJ), could suppress the proliferation of Hela and SiHa cells. Atr-I demonstrated a considerable antitumor effect in both human cervical cancer cells in vitro. Atr-I combined with P2X7R agonist, BzATP, restored Atr-I-induced growth inhibition in Hela cells but not in SiHa cells. However, the combinatorial treatment of P2X7R antagonist JNJ and Atr-I has an additive effect on cell growth inhibition in SiHa cells rather than in Hela cells. It implied that P2X7R would get involved in the anti-human cervical cancer cells effect of Atr-I.

show abstract