P300 Event-Related Potentials in Epileptic Children

Abstract

To evaluate the cognitive function of epileptic children, we examined P300 in 50 patients, 32 with idiopathic generalized epilepsy (IGE) and 18 with temporal lobe epilepsy (TLE), and 39 normal children. There were significant negative correlations between age and P300 latencies at Pz and Cz in normal controls. For data analysis, we used the age-corrected latency, which was calculated as the interval between the actual and predicted P300 latencies. The predicted latency was calculated with the regression equation as the relationship between P300 latency and age in normal controls. The age-corrected P300 latencies recorded from Pz and Cz were significantly longer in patients with IGE (41.5 +/- 13.1, 42.0 +/- 12.5) than in control subjects (0 +/- 7.5, 0 +/- 7.9). There were no significant differences in age-corrected P300 latencies between patients with TLE (21.2 +/- 17.6, 31.5 +/- 17.0) and controls, or IGE and TLE. Recently, it was considered that the mesencephalic reticular formation and thalamus may play major roles in the genesis of generalized epilepsy, so we speculate that dysfunction of these systems may contribute to the prolongation of P300 in children with idiopathic generalized epilepsy.

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

“…Sun et al 27 found that epilepsy duration was associated with delayed P300 latency. These findings were not confirmed in another studies 10,30 . It is known that P300 latency can increase when there is difficulty in the oddball paradigm 15 .…”

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

“…Event-related potential (ERP) is an important method to evaluate the cognitive status of epilepsy patients (e.g., Sunaga et al, 1994;Soysal et al, 1999;Rodin et al, 1999;Tendon and Duban, 2000;Trinka et al, 2000;Sun et al, 2007). Differences in timing and scalp topography of particular ERP components allow inferences about the timing and spatial characteristics of brain activity involved in cognitive processing (Rugg and Coles, 1995).…”

Event-Related Potentials for Cognitive Assessment of Patients with Epilepsy

“…In contrast, Sunaga showed significant differences in P300 latency with IGE, but not with TLE [3]. He speculated that dysfunction of the mesencephalic reticular formation and thalamus may contribute to prolongation of P300 in children with IGE [3]. On the other hand, Shimono [9], Chayasirisobhon [18] and Bocquillon [22] showed no significant difference in P300 latency with SPE or TLE.…”

“…Furthermore, patients with temporal lobe epilepsy (TLE) displayed prolonged P300 latencies compared to patients with IGE [2,12]. In contrast, Sunaga showed significant differences in P300 latency with IGE, but not with TLE [3]. He speculated that dysfunction of the mesencephalic reticular formation and thalamus may contribute to prolongation of P300 in children with IGE [3].…”