P3017 Functional analysis and association studies of bovine MYOT gene with meat quality

Adoligbé, Camus; Zan, L.; Farougou, Souaïbou

doi:10.2527/jas2016.94supplement459b

Cited by 4 publications

(1 citation statement)

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“…The other gene of interest that we identified is MYOT, which is associated with myofibril assembly and actin binding in muscle tissue [60]. Recent functional analysis revealed the association of mutations within MYOT with loin muscle area, backfat thickness and intramuscular fat in cattle [61]. Milk production and composition traits are under the control of multiple genes and are other economically important traits in dairy goat breeds.…”

Section: Selection Signature and Identification Of Candidate Genesmentioning

confidence: 99%

Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing

Gebreselase,

Nigussie,

Wang

et al. 2024

Animals

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Goats belong to a group of animals called small ruminants and are critical sources of livelihood for rural people. Genomic sequencing can provide information ranging from basic knowledge about goat diversity and evolutionary processes that shape genomes to functional information about genes/genomic regions. In this study, we exploited a whole-genome sequencing data set to analyze the genetic diversity, population structure and selection signatures of 44 individuals belonging to 5 Ethiopian goat populations: 12 Aberegalle (AB), 5 Afar (AF), 11 Begait (BG), 12 Central highlands (CH) and 5 Meafure (MR) goats. Our results revealed the highest genetic diversity in the BG goat population compared to the other goat populations. The pairwise genetic differentiation (FST) among the populations varied and ranged from 0.011 to 0.182, with the closest pairwise value (0.003) observed between the AB and CH goats and a distant correlation (FST = 0.182) between the BG and AB goats, indicating low to moderate genetic differentiation. Phylogenetic tree, ADMIXTURE and principal component analyses revealed a classification of the five Ethiopian goat breeds in accordance with their geographic distribution. We also found three top genomic regions that were detected under selection on chromosomes 2, 5 and 13. Moreover, this study identified different candidate genes related to milk characteristics (GLYCAM1 and SRC), carcass (ZNF385B, BMP-7, PDE1B, PPP1R1A, FTO and MYOT) and adaptive and immune response genes (MAPK13, MAPK14, SCN7A, IL12A, EST1 DEFB116 and DEFB119). In conclusion, this information could be helpful for understanding the genetic diversity and population structure and selection scanning of these important indigenous goats for future genetic improvement and/or as an intervention mechanism.

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Section: Selection Signature and Identification Of Candidate Genesmentioning

confidence: 99%

Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing

Gebreselase,

Nigussie,

Wang

et al. 2024

Animals

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Exploration of the genetic influence of MYOT and MB genes on the plumage coloration of Muscovy ducks

Sun,

Lu,

Duan

2024

Open Life Sciences

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Plumage color, a pivotal attribute delineating diverse Muscovy duck strains, assumes considerable significance within the field of Muscovy duck breeding research. This study extends the existing research by delving into the hereditary aspects of genes associated with plumage coloration in Muscovy ducks. The principal objective is to discern marker genes conducive to targeted breeding strategies based on plumage color, thereby furnishing indispensable technical foundations for the development of novel Muscovy duck varieties. Our investigation focused on scrutinizing the impact of MYOT and MB genes on the genetic expression of plumage color at both the RNA and protein levels in Muscovy ducks. The results elucidate that black Muscovy ducks manifest markedly elevated mRNA and protein expression levels of MYOT and MB genes in comparison to their white counterparts, indicating that both genes may play a constructive regulatory role in the context of plumage coloration in Muscovy ducks. The outcomes of this study delineate a discernible correlation between MYOT and MB genes and the plumage coloration in Muscovy ducks. Employing gene expression analysis, we successfully identified candidate genes that may be intricately linked to the determination of plumage color in these ducks.

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Detection of Genetic Differences between Holstein and Iranian North-West Indigenous Hybrid Cattles using Genomic Data

Biabani

Yeganeh²,

babak³

et al. 2022

rap

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P3017 Functional analysis and association studies of bovine MYOT gene with meat quality

Cited by 4 publications

References 0 publications

Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing

Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing

Exploration of the genetic influence of MYOT and MB genes on the plumage coloration of Muscovy ducks

Detection of Genetic Differences between Holstein and Iranian North-West Indigenous Hybrid Cattles using Genomic Data

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