P3239Poor outcome in chronic heart failure patients with thyroid hormones deficiencies

Terlizzese, Paola; Grande, Dario; Rizzo, Caterina; Parisi, G.; Gioia, Michele De; Leopizzi, Tiziana; Segreto, Antonio; Lattarulo, Michele; Licchelli, Brunella; Triggiani, Vincenzo; Iacoviello, Massimo

doi:10.1093/eurheartj/ehx504.p3239

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“…( 24 ) 2013 Germany Prospective 641 All-cause mortality HR 7 Chuang et al ( 25 ) 2014 China Prospective 106 All-cause mortality HR 8 Chen et al ( 26 ) 2015 China Retrospective 224 MACE HR (SC) 8 Okayama et al ( 27 ) 2015 Japan Retrospective 270 All-cause mortality/MACE/in-hospital mortality OR 8 Hayashi et al ( 7 ) 2016 Japan Prospective 274 MACE HR 8 Terlizzese et al . ( 28 ) 2017 Italy Prospective …”

Section: Resultsmentioning

confidence: 99%

Non-thyroidal illness syndrome and the prognosis of heart failure: a systematic review and meta-analysis

Qiu

Wang

et al. 2023

Endocrine Connections

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Background: Heart failure (HF) is a complex and multifactorial syndrome caused by impaired heart function. The high morbidity and mortality of HF cause a heavy burden of illness worldwide. Non-thyroidal illness syndrome (NTIS) refers to aberrant serum thyroid parameters in patients without past thyroid disease. Observational studies have indicated that NTIS is associated with a higher risk of all-cause mortality in HF. This meta-analysis aimed to investigate the association between NTIS and HF prognosis. Methods: Medline, Embase, Web of Science, and the Cochrane database were searched for any studies reporting an association between NTIS and HF prognosis from inception to July 1st 2022. A meta-analysis was then performed. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS). The heterogeneity of the results was assessed with I2 and Cochran's Q statistics. Sensitivity analysis and publication bias analysis were also conducted. Results: A total of 626 studies were retrieved, and 18 studies were finally included in the meta-analysis. The results showed that NTIS in HF patients was significantly associated with an increased risk of all-cause mortality and major cardiovascular events (MACE), but not with in-hospital mortality. The stability of the data was validated by the sensitivity analysis. There was no indication of a publication bias in the pooled results for all-cause mortality and MACE. Conclusions: This meta-analysis showed that NTIS was associated with a worse outcome in HF patients. However, the association between NTIS and in-hospital mortality of HF patients requires further investigation.

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