P3463Cardiac damage biomarkers profile after video-EEG documented seizures

Faria, Teresa; Rego, Ricardo; Sá, Francisca; Rocha, Helena; Farinha, Rui; Campelo, Manuel; Pinto, Ricardo Alves; Pestana, Gonçalo; Silva, M; Souteiro, Delfim; Pereira, Jorge; Gonçalves, Francisco Rocha; Martins, Elisabete

doi:10.1093/eurheartj/ehy563.p3463

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“…Following prolonged seizures, a considerable percentage of patients showed an increase in biomarkers of cardiac necrosis and dysfunction, which may indicate the onset of myocardial injury [ 11 ], but the prognostic value of this finding is not well defined.…”

Section: Introductionmentioning

confidence: 99%

Impact of Cardiac Injury on the Clinical Outcome of Children with Convulsive Status Epilepticus

et al. 2022

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Objectives: the aim of this study was to determine the impact of cardiac injury on clinical profile, cardiac evaluation and outcome in patients hospitalized with convulsive status epilepticus (CSE). Materials and methods: this prospective observational study included 74 children with CSE. Cardiac injury was evaluated and defined using combination of cardiac troponin, electrocardiography (ECG) and echocardiography. Clinical outcome and mortality rates were compared in patients with and without cardiac injury. Results: A total of 74 patients with CSE were included in the study. Thirty-six (48.6%) patients demonstrated markers of cardiac injury. ECG changes occurred in 45.9% and echocardiographic signs of left ventricular systolic and diastolic dysfunction reported in 5.4% and 8.1%, respectively. The mean length of hospital stays and need for ICU admission were significantly higher in patients with cardiac injury compared to others. One third of patients with cardiac injury needed mechanical ventilation and this was significantly higher than patients without (p = 0.042). hypotension and/or shock developed in 25% of cardiac injury patients and most of them required inotropic support; this was significantly higher than others without markers of cardiac injury. The overall mortality in cardiac injury group was higher (13.9% vs. 2.6%); however, this difference was not statistically significant. Conclusion: Markers of cardiac injury were common and associated with poor clinical outcome and higher risk of mortality in patients with CSE, so extensive routine cardiovascular evaluation is essential in these patients.

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Section: Introductionmentioning

confidence: 99%