P3551Right ventricular pacing for LVOT gradient reduction in hypertrophic obstructive cardiomyopathy: a meta-analysis and meta-regression of clinical trials

Arnold, Ahran; Howard, James P.; Ahmad, Yousif; Chiew, Kayla; Kerrigan, William J.; Vere, Felicity de; Keene, Daniel; Shun‐Shin, Matthew; Cole, Graham; Sohaib, Afzal; Varnava, Amanda; Francis, Dárrel P.; Whinnett, Zachary I.

doi:10.1093/eurheartj/ehy563.p3551

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“…Greater than 10 ms reduction in LVAT95 by HBP has previously been defined as resynchronization 4 : Changes in LVAT95 that are <10 ms cannot be distinguished from measurement variation. Therefore, the primary analysis was powered with a non-inferiority margin of 10 ms LVAT95 prolongation by NS-HBP compared to S-HBP.…”

Section: Discussionmentioning

confidence: 99%

“…The mean within-patient increase in RVAT95 was 16.8 ms. Although this is J o u r n a l P r e -p r o o f modest compared to HBP resynchronisation induced changes in activation time, which can be several times larger 4 , it is not necessarily trivial. BVP produces a similar magnitude of LVAT95 reduction in LBBB and this has important clinical effects of reduced mortality and morbidity 12 .…”

Section: Hbp Selectivity and Right Ventricular Synchronymentioning

confidence: 93%

“…and anatomical and temporal mis-annotation, therefore the activation time of 95% of activations (LVAT95) was used to quantify resynchronisation4 . Right ventricular activation time (RVAT95) was similarly calculated.…”

mentioning

confidence: 99%

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Left ventricular activation time and pattern are preserved with both selective and nonselective His bundle pacing

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Section: Discussionmentioning

confidence: 99%

Section: Hbp Selectivity and Right Ventricular Synchronymentioning

confidence: 93%