p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis

Weng, Yu; Lu, Liqin; Yuan, Guandou; Guo, Jìng; Zhang, Zhizhong; Xie, Xinyou; Chen, Guangdi; Zhang, Jun

doi:10.1371/journal.pone.0045820

Cited by 31 publications

(21 citation statements)

References 44 publications

(77 reference statements)

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“…For this, taking Arg/Arg homozygote as reference, the Arg/ Pro and Pro/Pro genotype risk on stomach cancer was examined. The dominant (Arg/Arg vs Arg/Pro+Pro/Pro) and recessive (Pro/Pro vs Arg/Arg+Arg/Pro) effects of the variant Pro/Pro allele (Zhang et al, 2010;Francisco et al, 2011;He et al, 2011;Weng et al, 2012) were also determined. For interactions study, tests were performed by making possible combinations for each p53 genotype with all the considered co-variables, and the univariate crude OR and multivariate adjusted OR were calculated.…”

Section: Discussionmentioning

confidence: 99%

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Substitution of a guanine base for cytosine in this codon leads to the replacement of an arginine amino acid to proline, which influences the activity of the resulting protein (12). The proline variant is effective in the repair of DNA damage, while the arginine variant leads to a strong induction of apoptosis (13). To date, studies have been performed on the P53 codon 72 polymorphism in breast, colorectal, skin and stomach cancers; however, no comprehensive result has been obtained (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

“…The proline variant is effective in the repair of DNA damage, while the arginine variant leads to a strong induction of apoptosis (13). To date, studies have been performed on the P53 codon 72 polymorphism in breast, colorectal, skin and stomach cancers; however, no comprehensive result has been obtained (13)(14)(15)(16). Considering the controversial results regarding the role of P53 gene polymorphism in gastric cancer, dependence of variants on geographical conditions, racial differences and genetic differences probably exists in different communities.…”

Section: Introductionmentioning

confidence: 99%

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

et al. 2018

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Abstract. Gastric cancer has the fourth highest morbidity rate of all cancers worldwide. Genetic factors including alterations in oncogenes and tumor suppressor genes serve an important role in gastric cancer development and progression. The P53 gene acts as a tumor suppressor gene by regulating the cell cycle, DNA transcription and repair, apoptosis, senescence and genome stability. In addition to somatic P53 mutations in cancer development, germline polymorphisms are also involved in different malignancies. The polymorphism of P53 at codon 72 (Arg72Pro) is established as a common variant that increases susceptibility to various cancers. The present case-control study was conducted to evaluate the possible association between this P53 polymorphism and gastric cancer in the Iranian population. A total of 59 patients with gastric cancer and 59 healthy controls were enrolled in the present study. Genomic DNA was extracted from peripheral blood mononuclear cells and genotype analysis was performed using a polymerase chain reaction-based restriction fragment length polymorphism assay. Genotype frequencies did not differ significantly between the patients and controls (P=0.4); the frequencies of the three genotypes Arg/Arg, Arg/Pro and Pro/Pro in gastric cancer patients were 28.8, 49.2 and 22.0%, and in controls were 37.3, 49.2 and 13.6%. Additionally, there were no differences in genotype frequencies based on tumor location, histological differentiation or tumor stage. Based on these findings, it may be concluded that the P53 codon 72 polymorphism does not contribute to gastric cancer susceptibility in Northern Iran. IntroductionGastric cancer has the third highest mortality and fourth highest morbidity rates of all cancers worldwide (1). In 2012, GloboCan statistics reported almost 1 million new cases of gastric cancer, and more than 700,000 mortalities caused by gastric cancer (1). Gastric cancer is a multifactorial disorder, in which genetic and environmental interactions serve an important role in development and progression (2). Increasing age, gender, lifestyle, dietary regime, environmental factors and Helicobacter pylori infections are among the known risk factors for stomach cancer (3,4). While dietary regime and lifestyle are the most recognized factors, more effective identification of the genetic risk factors is expected to improve understanding of the basic molecular events involved in tumorigenesis (5). Various genetic and epigenetic changes that have the potential to convert normal epithelial cells in the stomach into malignant neoplasms may be responsible for the development of both familial and sporadic gastric cancer (6,7). Studies performed recently have demonstrated that a high number of genes and various environmental factors are the causal agents of gastric cancer, and the presence of different forms of alleles in genes (polymorphisms) may promote the development of cancers; in this regard, the P53 gene has been a research focus due to its role as a major tumor suppressor gene (8,9). The P53 ge...

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“…As the reason for few studies were performed and there were many meta-analysis related on TP53 gene polymorphism and cancer risk (Weng et al, 2012;Zhao et al, 2013), we could not use meta-analysis to analyze the relationship between TP53BP1 rs2602141 A/C polymorphism combined with TP53 gene polymorphism and cancer. In addition, Rudd et al (Rudd et al, 2006) and Truong et al (Truong et al, 2010) found that rs2602141 polymorphism was associated with lung cancer risk.…”

Section: 2917 the P53-binding Protein 1 Rs2602141 A/c Snp And Cancermentioning

confidence: 99%

Association between the TP53BP1 rs2602141 A/C Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis

Liu

Zhang²,

Jiao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

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p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis

Cited by 31 publications

References 44 publications

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

Association between the TP53BP1 rs2602141 A/C Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis

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