P655 Molecular epidemiology associated with resistance in<i>neisseria gonorrhoeae</i>isolates from south brazil during 2008–2016

Golfetto, Lisléia; Schörner, Marcos André; Santos, Thais Mattos; Martins, Jéssica Motta; Machado, Hanalydia de Melo; Rocco, Felipe de; Scheffer, Mara Cristina; Silva, Emanuelle Da; Tobouti, Nina Reiko; Zoccoli, Cássia; Bazzo, Maria Luiza

doi:10.1136/sextrans-2019-sti.723

Cited by 1 publication

(2 citation statements)

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“…Consistent with WHO-GASP and ReLAVRA data, resistance to extended-spectrum cephalosporins remains infrequent in the LAC region. The percentage of strains with decreased susceptibility/resistance for ceftriaxone was between 0.09% (Argentina, 2011–2016) 53 and 7.2% (Argentina, 2005–2009) 45 , for cefixime it was between 0.2% (Argentina, 1993–not reported) 66 and 6% (Brazil, 2006–2015), 47 and for both combined it was 5.5% (Argentina, 2013–2015) 29 to 8.5% (Brazil, 2008–2016) 55 (Figure 3 ).…”

Section: Resultsmentioning

confidence: 94%

“…The studies provided data on AMR in the following countries: Argentina ( n = 10) 29 , 45 , 48 , 52–54 , 63 , 66 , 67 , 70 during 1993 and between 2000 and 2017; Brazil ( n = 9) 42 , 44 , 46 , 47 , 50 , 55 , 57 , 58 , 65 in 2003 to 2016; Colombia ( n = 2) 43 , 61 in 2009 to 2018; Peru ( n = 6) 56 , 59 , 60 , 62 , 68 , 69 in 2012 to 2017; Uruguay ( n = 1) 41 in 2010 and 2011; and Venezuela ( n = 1) 51 during 2008. There were also two studies reporting on AMR in various LAC countries from the WHO-GASP-LAC, one of which 49 reported resistance between 1990 and 2011 in 23 LAC countries, and the other reported data from 2010 and 2011 in seven LAC countries.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: a systematic review

Sandoval

Bardach

Rojas‐Roque

et al. 2023

Journal of Antimicrobial Chemotherapy

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Background Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC. Trial registration: Registered in PROSPERO, CRD42021253342.

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