P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma

Lazova, Rossitza; Tantcheva‐Poór, Iliana; Sigal, Alicia C.

doi:10.1016/j.jaad.2009.11.688

Cited by 46 publications

(31 citation statements)

References 31 publications

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“…Moreover, p75NTR is weakly expressed in the epithelioid melanomas, while it is highly expressed in desmoplastic and spindle cell melanomas (Iwamoto et al, 1996). This was confirmed by others who showed p75NTR staining to be more diffuse and intense as compared with S100 (Kanik et al, 1996;Lazova et al, 2010). On the contrary, Huttenbach and co-workers detected p75NTR positive cells only in 33% of desmoplastic melanomas (Huttenbach et al, 2002).…”

Section: Nts and Melanomasupporting

confidence: 52%

Melanoma and the Nervous System – Novel Pathways Mediated by Neurotrophins and Their Receptors

Pincelli¹,

Dallaglio²,

Truzzi³

2011

Breakthroughs in Melanoma Research

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Section: Nts and Melanomasupporting

confidence: 52%

Melanoma and the Nervous System – Novel Pathways Mediated by Neurotrophins and Their Receptors

Pincelli¹,

Dallaglio²,

Truzzi³

2011

Breakthroughs in Melanoma Research

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“…p75NTR is a transmembrane protein that binds nerve growth factor, and has been used as a marker of neural crest origin. 30 Bonetti et al 15 reported lack of p75NTR expression in non-neoplastic tissues and malignant peripheral nerve sheath tumors compared with the increased expression observed in schwannomas. Other groups reported high rates of expression in both schwannomas and malignant peripheral nerve sheath tumors in addition to numerous other tumors, including synovial sarcomas and rhabdomyosarcomas.…”

Section: Discussionmentioning

confidence: 99%

Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas

et al. 2015

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Cellular schwannoma is an uncommon, but well-recognized, benign peripheral nerve sheath tumor, which can be misdiagnosed as malignant peripheral nerve sheath tumor. To develop consensus diagnostic criteria for cellular schwannoma, we reviewed 115 malignant peripheral nerve sheath tumor and 26 cellular schwannoma cases from two institutions. Clinical data were retrieved from the electronic medical records, and morphologic features, maximal mitotic counts, Ki67 labeling indices, and immunohistochemical profiles (SOX10, SOX2, p75NTR, p16, p53, EGFR, and neurofibromin) were assessed. Several features distinguish cellular schwannoma from malignant peripheral nerve sheath tumor. First, in contrast to patients with malignant peripheral nerve sheath tumor, no metastases or disease-specific deaths were found in patients with cellular schwannoma. More specifically, 5-year progression-free survival rates were 100 and 18%, and 5-year disease-specific survival rates were 100 and 32% for cellular schwannoma and malignant peripheral nerve sheath tumor, respectively. Second, the presence of Schwannian whorls, a peritumoral capsule, subcapsular lymphocytes, macrophage-rich infiltrates, and the absence of fascicles favored the diagnosis of cellular schwannoma, while the presence of perivascular hypercellularity, tumor herniation into vascular lumens, and necrosis favor malignant peripheral nerve sheath tumor. Third, complete loss of SOX10, neurofibromin or p16 expression, or the presence of EGFR immunoreactivity was specific for malignant peripheral nerve sheath tumor (Po0.001 for each). Expression of p75NTR was observed in 80% of malignant peripheral nerve sheath tumors compared with 31% of cellular schwannomas (Po0.001). Fourth, Ki-67 labeling indices Z20% were highly predictive of malignant peripheral nerve sheath tumor (87% sensitivity and 96% specificity). Taken together, the combinations of these histopathological and immunohistochemical features provide useful criteria to distinguish between malignant peripheral nerve sheath tumor and cellular schwannoma with high sensitivity and specificity. Additional retrospective and prospective multicenter studies with larger data sets will be required to validate these findings.

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“…53 Interestingly, p75 NTR is highly expressed in desmoplastic melanomas and spindle cell melanomas and weakly expressed in the epithelioid melanomas. 54 In a study by Huttenbach et al only 33% of their desmoplastic melanomas stained positive with p75 NTR , 55 while more recently Lazova 56 showed p75 NTR staining to be more diffuse and intense as compared with S100, as reported previously by Kanik et al…”

Section: Neurotrophins In Diseased Skinmentioning

confidence: 62%

Neurotrophins in healthy and diseased skin

Truzzi

Marconi

Pincelli

2011

Dermato-Endocrinology

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Neurotrophins and Their ReceptorsNeurotrophins (NT) belong to a group of functionally and structurally related proteins that were first identified as promoters for neuronal survival. Subsequently, it was demonstrated that they regulate many aspects of neuronal development and function, like synapse formation and synaptic plasticity.1 Nerve growth factor (NGF) was the first NT to be discovered during a search for survival factors.2 Brain-derived neurotrophic factor (BDNF) was the second NT to be characterized. It has been identified as a survival factor for several neuronal populations not responsive to NGF.3 These two proteins revealed conserved features of the sequences, leading to isolation of clones encoding additional members of this family.Nowadays, we know that four NT are expressed in mammals: NGF, BDNF, NT-3 NT-4. NT play a critical role in developmental neurobiology. They play an essential role in cellular interactions, in controlling cell survival and differentiation. 4 NGF is internalized by receptor-dependent mechanisms and transported along axons in membranous vesicles and energy-dependent processes. Neurotrophins (NT) belong to a family of structurally and functionally related proteins that, depending on the tissue context and the receptors involved, promote either neuronal cell survival and differentiation or cell death. NT, and in particular NGF, were first identified as neurotrophic factors supporting the synthesis and development of sensory neurons in the central and peripheral nervous system. it is now widely accepted that NT also act as growth factors in non-neuronal cells, including the skin. in the skin, most cell types are able to secrete and/or to respond to stimulation by NT, creating a unique network of molecular signaling in the cutaneous microenvironment. Moreover, many skin diseases have been associated with an involvement of a number of neural factors including NT, but less attention has been given to the role of NT as growth factors in the development of skin pathologies. This review summarizes currently data on the expression and function of NT and their receptors in several cell types in the skin. Moreover it focuses on the role of the skin NT network in two cutaneous conditions, melanoma and psoriasis where NT are clearly involved.

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P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma

Cited by 46 publications

References 31 publications

Melanoma and the Nervous System – Novel Pathways Mediated by Neurotrophins and Their Receptors

Melanoma and the Nervous System – Novel Pathways Mediated by Neurotrophins and Their Receptors

Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas

Neurotrophins in healthy and diseased skin

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