PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats

Yuhara, Aki; Nishio, Chika; Abiru, Yasuhiro; Hatanaka, Hiroshi; Takei, Nobuyuki

doi:10.1016/s0165-3806(01)00249-8

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…PAC1-R is also maintained in areas of neurogenesis in the adult CNS, i.e., the hippocampal dentate gyrus [228,229]. These data corroborated with the findings by Yuhara et al [230], they showed the neurotrophic effects of PACAP on embryonic and early postnatal neurons as well as adult hippocampal cholinergic neurons. Similarly, recent studies by Mercer et al [229] and Yaka et al [231] have revealed that PACAP, via the activation of PKC signaling and the release of scaffolding protein RACK1 from NR2B and Fyn through cAMP/PKA pathway, is capable of inducing the neural stem cell proliferation by stimulating ex-novo formation of multipotent neurospheres in cultured neural stem cells.…”

Section: Actions In the Hippocampussupporting

confidence: 89%

The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System

Chu¹,

Lee²,

Siu³

et al. 2006

CNSAMC

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The secretin/PACAP/VIP superfamily contains at least ten brain-gut peptides, including secretin, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), glucagon, glucagon-like peptide-1 (GLP-1), glucagon like peptide-2 (GLP-2), gastric inhibitory polypeptide (GIP), peptide histidine isoleucine (PHI) or peptide histidine methionine (PHM), and growth hormone-releasing hormone (GHRH). These peptides exhibit a wide tissue distribution in the peripheral systems, indicating their pleiotrophic actions in the body. Meanwhile, their functions in the central nervious system (CNS) have also been consolidated recently. For instance, most of these peptides have shown to serve as neurotransmitters, neuromodulators, neurotrophic factors, and/or neurohormones in the brain, and hence, their potential as novel CNS agents in treating neurological disorders including Autism, Alzheimer's disease, Parkinson's disease and HIV-associated neuronal cell death were recently exploited. In this article, recent progress in research of peptides in this family with particular emphasis on structures, their central functions and potential use in the treatment of neuronal diseases are reviewed.

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Section: Actions In the Hippocampussupporting

confidence: 89%

The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System

Chu¹,

Lee²,

Siu³

et al. 2006

CNSAMC

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“…1E, application of PACAP38 (1μM) or PACAP27 (1μM) reduced the average rate of granule cell migration to 63 % and 61 % of the control values, respectively. Furthermore, we examined whether application of PACAP38 and PACAP27 alters the morphology of the leading process of migrating granule cells because it has been reported that PACAP38 and PACAP27 stimulates the extension (or outgrowth) of the neurite and axon of differentiating and mature neurons (Gonzalez et al, 1997,Yuhara et al, 2001Guirland et al, 2003;Fukiage et al, 2006;Lang et al, 2006). Interestingly, application of PACAP38 (1μM) or PACAP27 (1μM) significantly shortened the leading process of the migrating granule cells in the microexplant cultures ( Fig.…”

Section: Exogenous Pacap27 and Pacap38 Slow The Migration Of Isolatedmentioning

confidence: 95%

Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide

et al. 2007

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Migration of immature neurons is essential for forming the cortical layers and nuclei. Impairment of migration results in aberrant neuronal cytoarchitecture, which leads to various neurological disorders. Neurons alter the mode, tempo and rate of migration when they translocate through different cortical layers, but little is known about the mechanisms underlying this process. Here we show that endogenous pituitary adenylate cyclase-activating polypeptide (PACAP) has short-term and cortical-layer-specific effects on granule cell migration in the early postnatal mouse cerebellum. Application of exogenous PACAP significantly slowed the migration of isolated granule cells and shortened the leading process in the microexplant cultures of the postnatal day (P)0-3 cerebella. Interestingly, in the cerebellar slices of P10 mice, application of exogenous PACAP significantly inhibited granule cell migration in the external granular layer (EGL) and molecular layer (ML), but failed to alter the movement in the Purkinje cell layer (PCL) and internal granular layer (IGL). In contrast, application of PACAP antagonist accelerated granule cell migration in the PCL, but did not change the movement in the EGL, ML and IGL. Inhibition of the cAMP signaling and the activity of phospholipase C significantly reduced the effects of exogenous PACAP on granule cell migration. The PACAP action on granule cell migration was transient, and lasted for approximately 2 h. The duration of PACAP action on granule cell migration was determined by the desensitization of its receptors and prolonged by inhibiting the protein kinase C. Endogenous PACAP was present sporadically in the bottom of the ML, intensively in the PCL, and throughout the IGL. Collectively, these results indicated that PACAP acts on granule cell migration as "a brake (stop signal) for cell movement." Furthermore, these results suggest that endogenous PACAP slows granule cell migration when the cells enter the PACAP-rich PCL, and 2 h later the desensitization of PACAP receptors allows the cells to accelerate the rate of migration and to actively move within the PACAP-rich IGL. Therefore, endogenous PACAP may provide a cue that regulates granule cell migration in a cerebellar cortical-layer-specific manner.

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“…The presence of high concentrations of PACAP and its receptors in germinative areas of the developing brain indicates that the peptide may exert important functions during ontogenesis of the CNS. Indeed, PACAP exerts neurotrophic activities on many cell types (Yuhara et al, 2001;Erhardt and Sherwood, 2004;Nielsen et al, 2004;Reglodi et al, 2004;Reglödi et al, 2006;Shioda et al, 2006). In cerebellar granule cells cultured in conditions promoting apoptosis, PACAP inhibits programmed cell death (Campbell and Scanes, 1992;Canonico et al, 1996;Cavallaro et al, 1996;Chang et al, 1996;Gonzalez et al, 1997;Villalba et al, 1997) and stimulates neurite outgrowth (Fig.…”

Section: Actions Of Pituitary Adenylate Cyclase-activating Polypeptidmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats

Cited by 10 publications

References 23 publications

The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System

The Secretin/Pituitary Adenylate Cyclase-Activating Polypeptide/ Vasoactive Intestinal Polypeptide Superfamily in the Central Nervous System

Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

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