Paclitaxel enhanced radiation sensitization for the suppression of human prostate cancer tumor growth via a p53 independent pathway

Abstract

Pre-treatment with paclitaxel enhances radiation efficacy on cell killing and suppression of growth of human PC cell lines in vitro and in vivo via p53 independent pathways. Paclitaxel has potential for use as a radiosensitizer in the treatment of patients with PC with either wild-type or mutant p53 genetic status.

Chemoradiotherapy with taxane is superior to conventional surgery and radiotherapy in the management of cutaneous angiosarcoma: a multicentre, retrospective study

“…Thus, it is conceivable that taxane is also effective in the treatment of angiosarcoma. We were also attracted by the fact that taxane has been shown to have a radiosensitizing effect . In this context, we speculated that chemoradiotherapy with taxane might produce a greater response owing to their synergistic effect compared with receiving taxane chemotherapy alone.…”

“…We were also attracted by the fact that taxane has been shown to have a radiosensitizing effect. [17][18][19] In this context, we speculated that chemoradiotherapy with taxane might produce a greater response owing to their synergistic effect compared with receiving taxane chemotherapy alone. Moreover, patients who received maintenance chemotherapy achieved both a lower rate of distant metastasis (Table 6) and a higher survival rate than those who received T + RT alone (Fig.…”

Notch Inhibitor: a Promising Carcinoma Radiosensitizer

“…Although the exact mechanisms of action remain unclear, the majority of radiosensitizers can induce radiosensitization via the following pathways: (1) increased primary radiation damage (e.g., BrdU) (Dextraze et al,2009), (2) inhibition of DNA damage repair (e.g., HSP90 inhibitors NVP-AUY922) (Zaidi et al, 2012), (3) alteration of the cell cycle (e.g., tetrandrine; enhances radiosensitivity by relief of radiation-induced G2/M arrest ) and (4) enhanced apoptosis (e.g., Paclitaxel) (Zhang et al, 2007). Further, as CSCs contribute to radioresistance, targeting CSCs is another approach to decrease radioresistance.…”

Squamous cell carcinoma of neck metastasized to the lung and cervical lymph nodes, successfully treated with systemic docetaxel and local radiation therapy to the neck in a renal transplant patient

“…The efficacy of chemoradiotherapy with taxane in cutaneous angiosarcoma and prostate cancer has been proved. 4,5 Taxane demonstrates a radiosensitizing effect causing a high percentage of cells to arrest in the G2M phase when cells are most sensitive to irradiation. 5 The most impressive point in this case was the complete disappearance and non-recurrence of lung metastasis even after quitting chemotherapy.…”

“…4,5 Taxane demonstrates a radiosensitizing effect causing a high percentage of cells to arrest in the G2M phase when cells are most sensitive to irradiation. 5 The most impressive point in this case was the complete disappearance and non-recurrence of lung metastasis even after quitting chemotherapy. We propose that chemoradiotherapy with taxane could potentially be effective for SCC and other cancers as well.…”