Paclitaxel Exposure and its Effective Decontamination

Abstract

Background: Apart from generic guidelines for the safe handling of cytotoxic drugs in pharmacy departments, there is no specific published literature pertaining to cleaning procedures and inadvertent exposure to paclitaxel. Aim: To examine occupational exposure to paclitaxel; to identify an effective decontamination reagent; and to determine suitable glove type for skin protection. Method: 8 decontamination reagents were tested for paclitaxel degradation. Air sampling filters, Ghost Wipes and cotton wipes were tested under different storage conditions (room temperature, ≤ 4

Pilot Study Evaluating the Efficacy of Four Cleaning Solutions and Two Types of Mops in Delimited Areas of a Floor Contaminated with Cyclophosphamide

“…While sodium hypochlorite can cause discomfort to users in a room that is poorly ventilated, it should not be an issue in pharmacy cleanrooms where there are between 20 and 60 room air changes per hour. Numerous studies have been carried out with the aim of identifying an effective cleaning product able to decontaminate a surface contaminated with HDs [6][7][8][9][10][11][12][13]. Sodium hypochlorite alone or combined with sodium thiosulfate, hydrogen peroxide, potassium permanganate, isopropyl alcohol and Fenton reagent were among the most tested products.…”

“…For instance, it has been demonstrated that it can eliminate up to 98 % of the contamination on surfaces exposed to methotrexate, cytarabine, gemcitabine, etoposide phosphate, irinotecan, CP, ifosfamide, doxorubicin, epirubicin, and vincristine [7]. However, sodium hypochlorite can damage surfaces, may irritate the respiratory tract of exposed staff and is also potentially genotoxic for humans [12]. Touzin et al showed that a combination of sodium hypochlorite and sodium thiosulfate reduced 99.8 % of a contaminated area exposed to CP and that itcould theoretically prevent damage to surfaces [8].…”

Efficacy of Two Cleaning Solutions for the Decontamination of 10 Antineoplastic Agents in the Biosafety Cabinets of a Hospital Pharmacy

“…It is of utmost importance that an effective post drug-preparation cleaning procedure is carried out in these workstations in order to limit the accumulation of residual contamination, both chemical and microbiological. Several studies have been published on different cleaning procedures for surfaces contaminated by antineoplastic agents (Roberts et al, 2006;Lee et al, 2009;Queruau Lamerie et al, 2013;Le et al, 2013). Decontamination protocols involving sodium hypochlorite were considered effective for a variety of active ingredients, but they could damaged cleaned surfaces (need for rinsing after use) and were potentially genotoxic (Lee et al, 2009;Sharma et al, 2013).…”

“…Several studies have been published on different cleaning procedures for surfaces contaminated by antineoplastic agents (Roberts et al, 2006;Lee et al, 2009;Queruau Lamerie et al, 2013;Le et al, 2013). Decontamination protocols involving sodium hypochlorite were considered effective for a variety of active ingredients, but they could damaged cleaned surfaces (need for rinsing after use) and were potentially genotoxic (Lee et al, 2009;Sharma et al, 2013). Hydrogen peroxide, whether liquid or vaporized (VHP®), showed good decontamination and degradation action on 5-Fluorouracil, doxorubicin (DOX), and cyclophosphamide (CP) (Roberts et al, 2006).…”

Efficiency of four solutions in removing 23 conventional antineoplastic drugs from contaminated surfaces

“…Desorption strategies were studied on different antineoplastic drugs after intentional surface contamination. Some studies focused on 1 or 2 drugs [27][28][29][30][31][32], testing solutions of different natures (quaternary ammonium, biguanide, alcohol-based solutions). Others were performed on 10 drugs with a wider range of solutions (organic solvent; anionic, non-ionic or cationic surfactants; oxidant or water) [33].…”