Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells

Pradhan, Nibedita; Parbin, Sabnam; Kausar, Chahat; Kar, Swayamsiddha; Mawatwal, Shradha; Das, Laxmidhar; Deb, Moonmoon; Sengupta, Dipta; Dhiman, Rohan; Patra, Samir Kumar

doi:10.1016/j.fct.2019.05.016

Cited by 33 publications

(25 citation statements)

References 42 publications

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“…As an example, the natural methanolic extract from P. foetida leaves was shown to have antitumor effects in PCa cell lines, mechanistically resulting in downregulation of DNMT1, HDACs and various pro-inflammatory cytokines, including IL-6 and TNF-α. Authors believe that these compounds may, therefore, target epigenetic landscape of tumors, but also be used for promoting immune responses [159].…”

Section: Role Of Immunoepigenetics?mentioning

confidence: 99%

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Lobo

Jerónimo

Henrique

2020

IJMS

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In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic (chemo)therapies, given the associated short- and long-term side effects, by introducing more specific targeted therapies as single or combination agents. Due to the well-known implications of the immune system and epigenetic landscape in modulating cancer development, both have been explored as potential targets in several malignancies, including those affecting the genitourinary tract. As the immune system function is also epigenetically regulated, there is rationale for combining both strategies. However, this is still rather underexplored, namely in urological tumors. We aim to briefly review the use of immune therapies in prostate, kidney, bladder, and testicular cancer, and further describe studies providing supporting evidence on their combination with epigenetic-based therapies.

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Section: Role Of Immunoepigenetics?mentioning

confidence: 99%

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Lobo

Jerónimo

Henrique

2020

IJMS

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“…Bioactive molecules in the diet, such as the edible plant Celtis sagittata, demonstrated remarkable anti-cancer efficacy by regulating epigenetic signaling pathways and altering tumor-associated immune response. These compounds have anticancer functions in various cancer types by specifically inhibiting the activities of DNMTs and HDACs ( Pradhan et al, 2019 ). In addition, many epigenetic drugs have been tested in various stages of clinical trials ( Table 4 ).…”

Section: Epigenetic Regulators As Therapeutic Targets For Drug Developmentmentioning

confidence: 99%

Roles of Key Epigenetic Regulators in the Gene Transcription and Progression of Prostate Cancer

Deng

Xiao

Dai

et al. 2021

Front. Mol. Biosci.

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Prostate cancer (PCa) is a top-incidence malignancy, and the second most common cause of death amongst American men and the fifth leading cause of cancer death in men around the world. Androgen receptor (AR), the key transcription factor, is critical for the progression of PCa by regulating a series of target genes by androgen stimulation. A number of co-regulators of AR, including co-activators or co-repressors, have been implicated in AR-mediated gene transcription and PCa progression. Epigenetic regulators, by modifying chromatin integrity and accessibility for transcription regulation without altering DNA sequences, influence the transcriptional activity of AR and further regulate the gene expression of AR target genes in determining cell fate, PCa progression and therapeutic response. In this review, we summarized the structural interaction of AR and epigenetic regulators including histone or DNA methylation, histone acetylation or non-coding RNA, and functional synergy in PCa progression. Importantly, epigenetic regulators have been validated as diagnostic markers and therapeutic targets. A series of epigenetic target drugs have been developed, and have demonstrated the potential to treat PCa alone or in combination with antiandrogens.

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“…An aim of the experiment was an evaluation of the efficiency of plant in epigenetic modifications. Tested PC cells had a lower level of HDAC 1 and HDAC 2 expression after the application of the extract of PF leaves, lupeol and β-sitosterol, resulting in apoptosis, depression of viability, and suppression of cancer cells migration [148].…”

Section: Prostate Cancermentioning

confidence: 99%

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

et al. 2019

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Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.

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Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells

Cited by 33 publications

References 42 publications

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

Roles of Key Epigenetic Regulators in the Gene Transcription and Progression of Prostate Cancer

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

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