Paediatric Acute Generalized Exanthematous Pustulosis Induced by Paracetamol with High Serum Levels of Interleukin-8 and -22: A Case Report

Umayahara, Takatsune; Shimauchi, Takatoshi; Fujiyama, Toshiharu; Ito, Taisuke; Hirakawa, Satoshi; Tokura, Y.

doi:10.2340/00015555-1462

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Animal models for AGEP do not exist yet. T H 17 cells, IL-17 and IL-22, as well as the neutrophilic chemokine IL-8 were found to be markedly elevated in the peripheral blood of patients with active AGEP [ [85] , [86] , [87] ]. Studies on skin biopsies of patients also showed similar findings, supporting the T H 17-mediated pathophysiology in AGEP [ 88 , 89 ].…”

Section: Introductionmentioning

confidence: 99%

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Kan,

Tang,

2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Kan,

Tang,

2024

Heliyon

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“…Ancak, uzun süreli ilaç kullanımına bağlı AGEP gelişimi, sadece erişkin yaştaki malignite olgularında bildirilmiştir (11). Çocuklarda parasetamol' e bağlı AGEP gelişimi 7 yaşında bir olguda bildirilmiş, bu olguda da döküntü ilaçtan iki gün sonra ortaya çıkmıştır (12). Erişkinlerde de parasetamole bağlı AGEP olgulardaki döküntü de benzer sürede ortaya çıkmıştır (13).…”

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A Case of Acute Generalised Exanthematous Pustulosis Induced by Paracetamol

Kutluğ¹,

Celiksoy²,

Eroğlu³

et al. 2017

Asthma Allergy Immunol

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ÖZAkut jeneralize ekzantematöz püstülozis deri yüzeyinde eritem ve ödemin eşlik ettiği çok sayıda püstül ile karakterize ekzantematöz bir hastalıktır. Bu püstüller 5 mm'den küçük, nonfoliküler yerleşimli, steril ve yüzeyseldir. Hastalığın etiyolojisinde, başta antibiyotikler olmak üzere %90 oranında ilaçlar sorumludur. Viral enfeksiyonlar, civa maruziyeti ve örümcek ısırığı nadiren bildirilmiştir. Akut jeneralize ekzantematöz püstülozis'in mortalitesi %5 oranındadır. Bildirilen olguların büyük çoğunluğu erişkinlerdir. Çocuklarda AGEP nadiren bildirilmiştir. Bu olgu sunumunda, parasetamol sonrası akut jeneralize ekzantematöz püstülozis gelişen on aylık bir erkek hasta bildirilmiştir. ABSTRACTAcute generalized exanthematous pustulosis is an exanthematous disease characterized by a great number of pustules on an acutely erythematous and edematous surface on the skin. These pustules are smaller than 5 mm, have non-follicular localization, and are sterile and superficial. Drugs are held responsible for 90% of the cases and antibiotics are the main culprits. Viral infections, mercury exposure, spider bite and radiation have also been rarely reported as the causative agent. The mortality of AGEP, which is considered to be one of the Severe Cutaneous Adverse Reactions (SCAR), is 5%. Many of the cases reported are adults. Since AGEP is rare in children, we present a ten-month-old boy who developed AGEP after paracetamol use.

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Paracetamol

2013

Reactions Weekly

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Paediatric Acute Generalized Exanthematous Pustulosis Induced by Paracetamol with High Serum Levels of Interleukin-8 and -22: A Case Report

Cited by 6 publications

References 15 publications

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

A Case of Acute Generalised Exanthematous Pustulosis Induced by Paracetamol

Paracetamol

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