Paediatric clinical research from the perspective of hospital pharmacists from France and Canada

Guérin, Aurélie; Tanguay, Cynthia; Lebel, Denis; Prot-Labarthe, Sonia; Bourdon, Olivier; Bussières, Jean-François

doi:10.1111/ijpp.12099

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In France, surgery wards, pediatric services and intensive care units are areas where the development of the clinical pharmacy practice is still a work in progress. For example, in pediatrics, the implementation of this practice and clinical research studies are di cult to carry out due to nancial constraints and too small patient cohorts [22]; hence, only a few studies on clinical pharmacy practices are made in pediatrics. At international level however, we can cite studies on clinical pharmacy practices in pediatrics, such as two works by Italian [23] and Norwegian [24] researchers.…”

Section: Factors Associated With Pharmacists' Interventions Acceptancementioning

confidence: 99%

Characteristics and acceptance factors of pharmacists’ interventions from the national Act-IP© observatory: a six-year longitudinal study

Bouzeid

Clarenne

Mongaret

et al. 2022

Preprint

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Background In France, hospital pharmacists perform medication order reviews during patients’ hospitalization process. This activity can be centralized in the pharmacy or carried out directly in the ward, in contact with the healthcare team. During this review, pharmacists can perform pharmacists’ interventions to optimize therapeutics. Since 2006, they can document their interventions, via the national Act-IP© observatory. Aim To assess the characteristics of pharmacists’ interventions and their acceptance by physicians in French hospitals between 2014 and 2019. Method Between 2009 and 2014, we performed a 6-year observational study of pharmacists’ interventions documented on the Act-IP© French observatory. Results A total 194,684 pharmacists’ interventions were documented on the observatory and concerned mainly a “dosage adjustment” (25.6%). These interventions were mainly related to drugs from the central nervous system (23.7%). Seventy percent of pharmacists’ interventions were accepted by physicians. Acceptance rate was higher when conducted by a pharmacist regularly practicing in the ward (ORa = 1.60, CI 95 [1.57–1.64]). Physicians’ acceptance was significantly associated with 1) ward specialty: emergency (ORa = 1.24, CI 95 [1.14–1.35]); 2) type of intervention: “drug discontinuation”, “drug switch” (ORa = 1.15, CI 95 [1.12–1.19]) and “addition of a new drug” (ORa = 1.15, CI 95 [1.12–1.19]); 3) drug group: antineoplastic and immunomodulators (ORa = 3.67, CI 95 [3.44–3.92]), as well as blood and blood-forming organs (ORa = 1.10, CI 95 [1.05–1.20]). Conclusion This 6-year longitudinal study highlights the role of clinical pharmacists, and particularly those integrated into wards to improve both intervention acceptance and collaboration with physicians in patient care and drug safety.

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Section: Factors Associated With Pharmacists' Interventions Acceptancementioning

confidence: 99%

Characteristics and acceptance factors of pharmacists’ interventions from the national Act-IP© observatory: a six-year longitudinal study

Bouzeid

Clarenne

Mongaret

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Using national data to describe characteristics and determine acceptance factors of pharmacists’ interventions: a six-year longitudinal study

Bouzeid

Clarenne²,

Pluchart³

et al. 2022

Int J Clin Pharm

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Paediatric clinical research from the perspective of hospital pharmacists from France and Canada

Abstract: Difficulties related to pharmaceutical compounding were identified as the main hindrance to paediatric clinical research; particular attention should be paid to these details when setting up a paediatric trial.

Cited by 2 publications

References 7 publications

Characteristics and acceptance factors of pharmacists’ interventions from the national Act-IP© observatory: a six-year longitudinal study

Characteristics and acceptance factors of pharmacists’ interventions from the national Act-IP© observatory: a six-year longitudinal study

Using national data to describe characteristics and determine acceptance factors of pharmacists’ interventions: a six-year longitudinal study

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