Paediatric COVID-19: Milder Presentation—A Silver Lining in Dark Cloud

Ramteke, Sharmila; Tikkas, Rajesh; Goel, Manjusha; Mandraha, Shipra; Shrivastava, Jyotsna

doi:10.1093/tropej/fmaa106

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…Most articles (n = 223) used self-report methods. Table 1 summarizes the studies that used direct measures (n = 18), comprising actual taste tests administered either at home (Adamczyk et al, 2020;Hintschich et al, 2020a;Petrocelli et al, 2020b;Cao et al, 2021;Singer-Cornelius et al, 2021), at a testing facility (Altin et al, 2020;Bidkar et al, 2020a;Mazzatenta et al, 2020;Ramteke et al, 2020;Vaira et al, 2020a;Le Bon et al, 2021;Niklassen et al, 2021a;Salcan et al, 2021) or both in home and in a hospital environment (Vaira et al, 2020b(Vaira et al, , 2020c(Vaira et al, , 2020d. Vaira et al [2020e] had an unknown testing location.…”

Section: Data Extractionmentioning

confidence: 99%

“…Murat et al, 2020;Nakagawa et al, 2020Nakagawa et al, , 2020Nakakubo et al, 2020;Nakanishi et al, 2020;Noh et al, 2020;Otte et al, 2020;Ozcelik Korkmaz et al, 2020;Paderno et al, 2020;Patel et al, 2020;Perlman et al, 2020;Petersen et al, 2020;Petrocelli et al, 2020bPetrocelli et al, , 2020aPinna et al, 2020;Printza et al, 2020Printza et al, , 2021Qiu et al, 2020;Rajkumar et al, 2020;Ramteke et al, 2020Ramteke et al, , 2020Rojas-Lechuga et al, 2020;Roland et al, 2020;Romero-Sanchez et al, 2020; Rubel et al, 2020;Sakalli et al, 2020;Salepci et al, 2020;Sayin et al, 2020aSayin et al, , 2020bSchirinzi et al, 2020;Schmithausen et al, 2020;Seo et al, 2020;Shoer et al, 2020;Sierpinski et al, 2020;Smith et al, 2020;Somekh et al, 2020; Speth et al, 2020;Spinato et al, 2020;Stavem et al, 2020; Sun et al, 2020;Teklu et al, 2020;Tham et al, 2020;Tsivgou...…”

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RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

et al. 2022

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Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before COVID-19 taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID-19 patients, we conducted a systematic review and meta-analysis of 376 papers published in 2020–2021, with 241 meeting all inclusion criteria. Drawing on previous studies and guided by early meta-analyses, we explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized that direct measures of taste are at least as sensitive as those obtained by self-report and that the preponderance of evidence confirms taste loss is a symptom of COVID-19. The meta-analysis showed that, among 138,897 COVID-19-positive patients, 39.2% reported taste dysfunction (95% confidence interval: 35.34%–43.12%), and the prevalence estimates were slightly but not significantly higher from studies using direct (n = 18) versus self-report (n = 223) methodologies (Q = 0.57, df = 1, P = 0.45). Generally, males reported lower rates of taste loss than did females, and taste loss was highest among middle-aged adults. Thus, taste loss is likely a bona fide symptom of COVID-19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.

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Section: Data Extractionmentioning

confidence: 99%

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RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

et al. 2022

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Taste loss as a distinct symptom of COVID-19: A systematic review and meta-analysis

Hannum

Koch

Ramirez

et al. 2021

Preprint

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Chemosensory scientists have been skeptical that reports of COVID–19 taste loss are genuine, in part because, before COVID–19, taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID–19 patients, we conducted a systematic review and meta–analysis of 376 papers published in 2020 and 2021, with 241 of the papers meeting all inclusion criteria. Additionally, we explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized that direct prevalence measures of taste loss would be the most valid because they avoid the taste/smell confusion of self-report. The meta–analysis showed that, among 138,897 COVID–19–positive patients, 39.2% reported taste dysfunction (95% CI: 35.34–43.12%), and the prevalence estimates were slightly but not significantly higher from studies using direct (n = 18) versus self-report (n = 223) methodologies (Q = 0.57, df = 1, p = 0.45). Generally, males reported lower rates of taste loss than did females and taste loss was highest in middle-aged groups. Thus, taste loss is a bona fide symptom COVID–19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.

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“…Children are found to be less affected with COVID-19 with majority of them presenting with milder symptoms. [ 43 ] Macias-Parra et al . [ 44 ] and Jat et al .…”

Section: Discussionmentioning

confidence: 99%

Gender and genetic factors impacting COVID-19 severity

Mishra

Ranjan

Ravindra

2021

Journal of Family Medicine and Primary Care

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COVID-19 pandemic is a cause of global concern and is impacting lives and economy globally. Infection due to SARS-CoV-2 leads to varied clinical manifestations, which can vary from asymptomatic to severe acute respiratory syndrome and death. The clinical features are proposed to depend upon various host factors, namely, gender and genetic factors. The significantly high mortality among males has revealed the role of gender, androgens, age, genetics, and risk factors in determining the severity of COVID-19 among the population. The interplay of various host factors and their association with clinically severe infections is crucial for our understanding of COVID-19 pathogenesis. A PubMed and Google scholar search was made using keywords such as “COVID-19 + sex differences,” “COVID-19 + androgens,” “COVID-19 + ACE2 receptor,” and “COVID-19 + smoking alcoholism pregnancy.” The articles which highlight the association of gender and genetic factors to COVID-19 were selected and included in our study. It is mainly the primary care or family physicians who act as the first contact of COVID-19 patients. With the recent increase in SARS-CoV-2 infections in the Indian subcontinent and probability of upcoming surges, it has become imperative to understand its interaction with the various gender and genetic factors to devise effective triage and management protocols. Our review highlights the possible mechanisms by which these factors impact the severity of COVID-19. A better understanding of these factors will be of immense help to primary care physicians.

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Paediatric COVID-19: Milder Presentation—A Silver Lining in Dark Cloud

Cited by 8 publications

References 7 publications

RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

Taste loss as a distinct symptom of COVID-19: A systematic review and meta-analysis

Gender and genetic factors impacting COVID-19 severity

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