Paediatric partial‐thickness scald burns – is Biobrane the best treatment available?

Mandal, Anirban

doi:10.1111/j.1742-481x.2006.00279.x

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…[14] Biobrane® also significantly reduces hospital stay, wound healing time and requirements of pain medications. [15] There are reported applications in patients with toxic epidermal necrosis, chronic wounds, or following skin resurfacing. [13]…”

Section: Classificationsmentioning

confidence: 99%

Biologic and synthetic skin substitutes: An overview

Halim

Khoo

Yussof

2010

Indian J Plast Surg

314

169

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The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesised on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialisation characteristics due to the presence of a basement membrane. Synthetic skin substitutes demonstrate the advantages of increase control over scaffold composition. The ultimate goal is to achieve an ideal skin substitute that provides an effective and scar-free wound healing.

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Section: Classificationsmentioning

confidence: 99%

Biologic and synthetic skin substitutes: An overview

Halim

Khoo

Yussof

2010

Indian J Plast Surg

314

169

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“…38 Mandal et al reported on the basis of scanty prospective comparative studies that Biobrane seemed to be more effective with regard to wound healing, pain control, and LOS than conservative treatment, including SSD in pediatric patients. 39 A recent Cochrane review, based mainly on adult patients, found also that SSD was consistently associated with poorer healing outcomes. 8 Finally, a similar systematic review of seven RCTs comparing silver dressings and topical silver to nonsilver dressings found a longer healing time for partial-thickness burns when silver dressings were compared with nonsilver treatment in adults (WMD: 3.96 days; 95% CI: 2.41, 5.5).…”

Section: Discussionmentioning

confidence: 99%

Nonsilver treatment vs. silver sulfadiazine in treatment of partial‐thickness burn wounds in children: A systematic review and meta‐analysis

Rashaan

Krijnen

Klamer

et al. 2014

Wound Repair Regeneration

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The evidence for application of silver-containing dressings and topicals in the treatment of partial-thickness burns in pediatric patients is largely based on clinical trials involving adult patients despite the important differences between the skin of children and adults. A systematic review and meta-analysis was performed of all randomized controlled trials comparing nonsilver treatment with silver-containing dressings and silver topical agents in children with partial-thickness burns in the acute stage. Endpoints were wound healing, grafting, infection, pain, number of dressing changes, length of hospital stay, and scarring. Seven randomized controlled trials were included involving 473 participants. All trials used silver sulfadiazine as control in comparison with five different nonsilver treatments. Most trials were of moderate quality with high risk of bias. Use of nonsilver treatment led to shorter wound healing time (weighted mean difference: -3.43 days, 95% confidence interval: -4.78, -2.07), less dressing changes (weighted mean difference: -19.89 dressing changes, 95% confidence interval: -38.12, -1.66), and shorter length of hospital stay (weighted mean difference: -2.07 days, 95% confidence interval: -2.63, -1.50) compared with silver sulfadiazine treatment, but no difference in the incidence of wound infection or grafting was found. In conclusion, nonsilver treatment may be preferred over silver sulfadiazine, but high-quality randomized controlled trials are needed to validly confirm the effectiveness of silver containing preparations, in particular silver-containing dressings, above nonsilver treatments.

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“…Sin embargo, otros estudios sobre el uso de coberturas de heridas con nanopartículas de plata aún son controvertidos [54] y la recomendación ha sido solicitar estudios de calidad para comprobar la eficacia del producto [55]- [57]. Hay evidencia que demuestra que la cicatrización de heridas y quemaduras puede acelerarse mediante el uso de nanopartículas gal [58] o con sustitutos de piel biosintéticos [59], [60]. La evidencia disponible sugiere que los apósitos de miel promueven una mejor cicatrización de heridas que la sulfadiazina de plata para las quemaduras [61].…”

Section: Impacto De Las Nuevas Tecnologías En La Reparación De Las Leunclassified

Revisión normativa y conceptual relacionada con la incapacidad medicolegal en Colombia

Támara-Patiño¹,

Fontanilla-Duque²

2019

Colomb. forense

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Propósito: actualmente, el avance médico tecnológico en diagnóstico, terapéuticas y rehabilitación exige la revisión de los parámetros de la valoración medicolegal de las personas que acuden al sector justicia colombiano. Para ello, se recopila información normativa y conceptual sobre las lesiones no fatales, especialmente en lo relacionado con los tiempos de reparación y los factores que los afectan. Periodo que se abarcó, origen y tipos de publicaciones: el periodo abarcado para el análisis conceptual es del año 2006 al 2018, con artículos recopilados de PubMed y Science Direct sin ninguna preferencia en cuanto al origen. Se realiza revisión legislativa nacional relacionada. Punto de vista: aunque la determinación de la reparación de las lesiones se establecía como punto de partida para definir las incapacidades medicolegales, su variabilidad y el impacto de las nuevas tecnologías en salud amerita resignificar las formas de medir estos tiempos de manera individualizada. Conclusiones: es imprescindible avanzar en estudios de investigación en nuestros grupos poblacionales, que permitan tener información para el sector forense.

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Paediatric partial‐thickness scald burns – is Biobrane the best treatment available?

Cited by 20 publications

References 22 publications

Biologic and synthetic skin substitutes: An overview

Biologic and synthetic skin substitutes: An overview

Nonsilver treatment vs. silver sulfadiazine in treatment of partial‐thickness burn wounds in children: A systematic review and meta‐analysis

Revisión normativa y conceptual relacionada con la incapacidad medicolegal en Colombia

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