Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice

A Novel Soluble Beta-Glucan Salecan Protects against Acute Alcohol-Induced Hepatotoxicity in Mice

“…It is generally believed that the accumulation of triglyceride in the hepatocytes is first hit, which leads to inflammation and acts as lipotoxicity in alcoholinduced liver injury. 22) Our findings indicate that salecan alleviates ethanol-induced hepatic fatty accumulation, as evidenced by H and E and Oil Red O staining. Furthermore, an important component responsible for triacylglycerol synthesis, DGAT1, was downregulated by salecan after ethanol ingestion.…”

Genetic diversity and phylogenetic analysis of genus Paeonia based on nuclear ribosomal DNA ITS sequence

“…Many species of this genus have been used in traditional folk medicine, such as the roots of P. suffruticosa, P. lactiflora, P. obovata, and P. albiflora are the most important crude drugs in Traditional Chinese Medicine (TCM), and have been used as analgesic, sedative, and anti-inflammatory agents, and as remedies for cardiovarscular, extravasated blood, stagnated blood, and female genital diseases (Chang and But 1986;Wu 1990). Phytochemical investigations of Paeonia species have also revealed their main components exhibit significant biological and pharmacological activities (Tsai et al 2008;Hu et al 2010).…”

Paeonol produced by Chaetomium sp., an endophytic fungus isolated from Paeonia suffruticosa

“…The pharmacological avtivity of paeonol is widely, the researchers found that paeonol plays a role in vascular disease, anti-tumor, anti-aging, the elimination of inflammation and immuned system diseases (Jamal et al, 2014;Zhou et al, 2011;Cai et al, 2014;Wu et al, 2014a,b;Peng et al, 2013;Hu et al, 2010;Kim et al, 2004). At present, paeonol is mainly extracted by Cortex Moutan; there were reports that paeonol was prepared by chemical synthesis (Gao et al, 2008), but there were no relevant reports that endophytic fungi could procuce paeonol.…”