Paget-type Recurrence 10 Years after Breast-conserving Therapy for Breast Cancer

Abstract

2)We report a case of Paget-type recurrence 10 years after breast-conserving therapy. The patient was a 51-year-old woman who, at first surgery, had undergone quadrantectomy and axillary dissection with radiotherapy for non-invasive ductal carcinoma of the left breast. An erythematous lesion appeared in the ipsilateral nipple-areolar region 10 years after the first surgery. Skin biopsy revealed that it was a Bowen's disease-like lesion associated with no lesion in the breast. She underwent local excision involving the subdermal and mammary tissue under the skin lesion. Postoperative pathohistological examination revealed Paget-like cells in the epidermis and ductal carcinoma in situ in the nipple. The tumor cells were positive for CK7 and HER2 but negative for CK20, ER, PgR, and GCDFP15 by immunohistochemical study. We concluded that it was Paget-type recurrence 10 years after breastconserving therapy. She received adjuvant chemotherapy and no recurrent lesion has been detected.