Pain Perception and the Opioid Receptor Delta 1

Abstract

Genetic factors play an integral role in the perception of pain, and studies have only recently begun to explore the degree to which these factors affect clinical decisions. The process of prescribing opioids is greatly influenced by an individual's pain perception, which can vary based on several factors including genetic variation. Opioid receptor delta 1 (OPRD1) plays a significant role in the perception of both pain and its relief via opioids, and it shows significant variability between individuals. Herein, we discuss the nature of the OPRD1 receptor and the value of further research into its effects, particularly in the realm of pain management.

Personalized Pediatric Anesthesia and Pain Management: Problem-Based Review

“…Polymorphisms of KCNJ6 (1250G>A and 1032A>G) may affect opioid response; however, the evidence is sparse and inconclusive [63]. Polymorphisms of the OPRD1 gene, coding for delta-opioid receptor, have also been described [64]. Table 2 provides an overview of significant genetic variants relevant to anesthesia providers.…”

Changes in the Cell Squad of Iliac Lymph Nodes of White Rats in Case of Longterm Influence of Nalbufin

“…The study of the influence of narcotic analgesics, in particular opioids, on the immune system of the body, is one of the most important problems, since they are widely used in medical practice [1]. Their medical and social significance is primarily associated with a painkilleractivity [2,3]. The opioid is a substance of synthetic and semi-synthetic origin, which is in its composition,morphochemically, related to opiate receptors and provides a certain psycho-vegetative action.…”