Pain treatment with a COX-2 inhibitor after coronary artery bypass operation: a randomized trial

Immer, Franz F.; Immer-Bansi, Alexsandra S; Trachsel, Nathalie; Berdat, Pascal A.; Eigenmann, Verena; Curatolo, Michele; Carrel, Thierry

doi:10.1016/s0003-4975(02)04311-4

Cited by 40 publications

(34 citation statements)

References 21 publications

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“…Normally, postoperative pain is the most intense immediately after the operation and then decreases over time according to measurements using the FACES scale [11,12]. In the current study, however, a different pattern of pain was observed due to the continuous epidural anesthesia given for 2 days immediately after surgery.…”

Section: Discussioncontrasting

confidence: 60%

Assessment of pain by face scales after gastrectomy: comparison of laparoscopically assisted gastrectomy and open gastrectomy

et al. 2008

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Section: Discussioncontrasting

confidence: 60%

Assessment of pain by face scales after gastrectomy: comparison of laparoscopically assisted gastrectomy and open gastrectomy

et al. 2008

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“…A similar observation had already been reported by others in patients treated with etodolac after coronary artery bypass operation, although the design of that study was different from ours [14]; that study demonstrated that etodolac given on postoperative days 2 and 3 reduced postoperative pain after CABG.…”

Section: Discussionsupporting

confidence: 89%

Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery

Koizuka

Saito

Obata

et al. 2004

Journal of Anesthesia

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“…Of these, ten were excluded for the following reasons: non-random design, [14][15][16] NSAIDs given to all randomized groups, 17,18 non-cardiothoracic surgery 19 and use of COX-2 selective NSAIDs. [20][21][22][23] Therefore, 20 randomized trials (19 papers and one abstract) involving a total of 1,065 patients provided data for this meta-analysis. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] Table I outlines the characteristics of included trials.…”

Section: Resultsmentioning

confidence: 99%

NSAID-analgesia, pain control and morbidity in cardiothoracic surgery

Bainbridge

Cheng

Martin

et al. 2006

Can J Anesth/J Can Anesth

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Objective: While narcotics remain the backbone of perioperative analgesia, the adjunctive role of other analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs), is being recognized increasingly. This meta-analysis sought to determine whether adjunctive NSAIDs improve postoperative analgesia and reduce cumulative narcotic requirements. Methods:A comprehensive search was undertaken to identify all randomized trials, in cardiothoracic patients, of NSAIDs plus narcotics vs narcotics without NSAIDs. Medline, Cochrane Library, EMBASE, and abstract databases were searched up to September 2005. The primary outcome was visual analogue scale (VAS) pain score. Secondary outcomes included 24-hr cumulative morphine-equivalents, rescue medications required, mortality, myocardial infarction, atrial fibrillation, stroke, renal failure, hospital readmissions, and in-hospital costs.Results: Twenty randomized trials involving 1,065 patients were included. A significant reduction in 24-hr VAS pain score was found in patients receiving NSAIDs [weighted mean difference (WMD) -0.91 points, 95% confidence interval (CI) -1.48 to -0.34 points]. In addition, patients required significantly less morphine-equivalents in the first 24 hr (WMD -7.67 mg, 95% CI -8.97 to -6.38 mg). No significant difference was found with respect to mortality [odds ratio (OR) 0.19, 95% CI 0.01 to 4.22], myocardial infarction (OR 0.71, 95% CI 0.09 to 5.71), renal dysfunction (OR 0.95, 95% CI 0.37 to 2.46), or gastrointestinal bleeding (OR 0.96, 95% CI 0.13 to 7.09). Conclusion:In patients less than 70 yr of age undergoing cardiothoracic surgery, the adjunctive use of NSAIDs with narcotic analgesia reduces 24-hr VAS pain score and narcotic requirements. 67 mg,38 mg). Il n'y avait aucune différence significative quant à la mortalité [risque relatif (RR) de 0,19, IC de 95 % 0,01 à 4,22], à l'infarctus du myocarde (RR 0,71, IC de 95 % 0,09 à 5,71), à l'insuffisance rénale (RR 0,5, IC de 95 % 0,37 à 2,46) ou au saignement gastrointestinal (RR 0,96, IC de 95 % 0,13 à 7,09 Objectif

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Pain treatment with a COX-2 inhibitor after coronary artery bypass operation: a randomized trial

Cited by 40 publications

References 21 publications

Assessment of pain by face scales after gastrectomy: comparison of laparoscopically assisted gastrectomy and open gastrectomy

Assessment of pain by face scales after gastrectomy: comparison of laparoscopically assisted gastrectomy and open gastrectomy

Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery

NSAID-analgesia, pain control and morbidity in cardiothoracic surgery

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