PainVision® Apparatus for Assessment of Efficacy of Pulsed Radiofrequency Combined with Pharmacological Therapy in the Treatment of Postherpetic Neuralgia and Correlations with Measurements

Wang, Dong; Zhang, Kai; Han, Shaolong; Lan, Yu

doi:10.1155/2017/5670219

Cited by 19 publications

(27 citation statements)

References 17 publications

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“…The total number of the participants was 631, and sample capacity ranged from 33 to 270. There was no difference of gender ratio in four studies[13141516] and the other two studies did not make gender comparison between the intervention group and the control group. [1718] The average age of all the participants age was above 59.…”

Section: Resultsmentioning

confidence: 99%

The effect of interventional pain management on treating postherpetic neuralgia

et al. 2019

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Background: Herpes zoster (HZ) is identified to induce postherpetic neuralgia (PHN) which is difficult to cure. PHN-related pain brings patients not only physical discomfort but also mental depression and anxiety. Currently, the main purpose of PHN treatment is to reduce patients’ pain. Now treatment combining some international pain management and drug therapy has come up. Aims and Objective: This study aims to evaluate the effect of interventional management through meta-analysis. Materials and Methods: Interventional pain management was defined as a direct strategy on nerve through physical or chemical method. Drug therapy was always regarded as control. Potentially relevant articles were searched in PubMed, EMBASE, and the Cochrane Library through key words by consensus. Pain severity was evaluated by a validated visual analog scale (VAS). Moreover, the weighted mean difference was used to calculate pain intensity. Some trails recorded the efficiency rate and odds ratio was used to calculate the effectiveness. Statistical heterogeneity was measured by the value of I 2 , and when statistical I 2 > 50%, subgroup analysis was used to seek for the source of heterogeneity. Results: Pulsed radiofrequency (PRF) combined with medication reduced the VAS scores at 1, 2, 4, and 8 weeks after treatment. The nerve block combined with medication reduced VAS scores at 8 weeks after treatment, but there is no difference between the results of medication alone at 1, 2, and 4 weeks after treatment. Conclusion: The interventional mean of PRF combined with medication has a good effect on PHN. The effect of nerve block combined with medication on PHN seems to be the same as that of medication alone. Besides, a long period with high-quality randomized controlled trial should be done to verify the results.

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Section: Resultsmentioning

confidence: 99%

The effect of interventional pain management on treating postherpetic neuralgia

et al. 2019

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“…This research was conducted with approval from the ethics committee of Tohoku Bunka Gakuen University (approval number [16][17][18][19][20][21][22][23]. Participants received written information explaining the purpose of the study, and informed consent was obtained from all participants included in the study.…”

Section: Participantsmentioning

confidence: 99%

“…The participants wore the stimulation electrode on the inside of the forearm of their non-dominant hand and had a hand switch in their dominant hand to report sensation of current from the stimulation electrode. During the evaluation, the minimum current perception threshold at which the subject felt stimulation (minimum perceived current) and the amount of current corresponding to the pain (pain equivalent current) were measured, and the degree of pain was calculated (15)(16)(17)(18)(19). The stimulation current automatically and gradually increased from 0 µA.…”

Section: Evaluation Of Painmentioning

confidence: 99%

Analgesia by sacral surface electrical stimulation for primary dysmenorrhoea

et al. 2020

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Objective: To evaluate the effects of analgesia by sacral surface electrical stimulation on lower abdominal pain in women with primary dysmenorrhoea. Design: Explorative study. Participants: Eleven female university students, who regularly experience difficulty in their university work due to menstrual pain, or who use analgesics for more than one day each month, were recruited. Methods: Sacral surface electrical stimulation, 5 Hz for 15 min, was performed after the onset of menstruation. Electrodes were placed on the skin, directly above the second and fourth sacral foramina. Visual analogue scale and degree of pain (calculated by using a low current to assess pain) were determined before and after electrical stimulation. Results: Visual analogue scale score and degree of pain decreased significantly immediately after electrical stimulation (p < 0.001). A correlation was observed between visual analogue scale score and degree of pain before and after electrical stimulation (r=0.516, p < 0.001). No side-effects were observed in any participant. Conclusion: Sacral surface electrical stimulation may provide immediate pain relief in women with dysmenorrhoea and lower abdominal pain.

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“…By stimulating Ca release from synapses, PGB decreases the release of neurotransmitters such as glutamate and norepinephrine [ 2 ]. Pregabalin is used in many fields of medicine, including orthopedics, to relieve post-operative peripheral neuropathic pain [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1α, and COL2A1 gene expression

Şirin¹,

Karaarslan²

2018

aoms

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IntroductionThe aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1-α (HIF-1α), and chondroadherin (CHAD) gene expression in osteoarthritic chondrocytes.Material and methodsStandard primary chondrocyte cultures were prepared using osteochondral tissues that were surgically obtained from 6 patients with gonarthrosis. Cell morphology was evaluated using an inverted microscope, and cell death and proliferation were determined through MTT analysis, which was confirmed by AO/PI staining and statistically evaluated. The expression levels of CHAD, COL2A1, and HIF-1α genes were assessed using gene-specific TaqMan Gene Expression Assays.ResultsMTT analyses showed that PGB administration did not have a negative or toxic effect on cell viability and proliferation in cultured chondrocytes (p < 0.001), but in our morphological evaluation extracellular matrix development was observed to be weaker in cultures treated with PGB. After 24 h of treatment, COL2A1, HIF-1α, and CHAD gene expression decreased in the groups to which PGB was applied compared to gene expression before the experiment (at 0 h); at 48 h, CHAD and HIF-1α expression increased to the same level as the control group, but the expression of COL2A1 continued to decrease.ConclusionsFurther studies need to be conducted with more participants to prove that there is a negative correlation between extracellular matrix formation and PGB administration. Our preliminary data show that even at low doses and over short-term administration, PGB may affect chondrocyte cells at the gene-expression level.

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PainVision® Apparatus for Assessment of Efficacy of Pulsed Radiofrequency Combined with Pharmacological Therapy in the Treatment of Postherpetic Neuralgia and Correlations with Measurements

Cited by 19 publications

References 17 publications

The effect of interventional pain management on treating postherpetic neuralgia

The effect of interventional pain management on treating postherpetic neuralgia

Analgesia by sacral surface electrical stimulation for primary dysmenorrhoea

Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1α, and COL2A1 gene expression

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