Since the coronavirus disease 2019, called COVID-19, has overwhelmed the high-income countries with ample resources and established healthcare system, we argue that there are plausible concerns why it may devastate the low-income countries like Pakistan. Focusing on Pakistan, we highlight the underlying reasons—e.g., demographic features, ineffective healthcare system, economic and social inequalities, corruption, and socio-cultural characteristics—that create fertile grounds for COVID-19 to overwhelm low-income countries. This paper presents Pakistan’s brief profile to demonstrate these underlying structures that may make the country more vulnerable in the face of an unceasing COVID-19 pandemic. The paper concludes that the country may make appropriate and possible effective short-term preparedness measures to halt or slow the transmission of the virus, and deal with its current implications as well as it may pay significant attention to long-term measures to deal effectively with COVID-19 longer-term effects. These measures may help Pakistan to deal appropriately with a similar future critical event.