Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner

Silva, Sara Pereira; Beserra-Filho, José Ivo Araújo; Kubota, Melina Chiemi; Cardoso, Gabriela Nascimento; Freitas, Francisca; Gonçalves, Bianca Santos Martins; Vicente-Silva, Wilson; Silva-Martins, Suellen; Custódio-Silva, Ana Cláudia; Soares-Silva, Beatriz; Maria-Macêdo, Amanda; Santos, José R.; Estadella, Débora; Ribeiro, Alessandra Mussi

doi:10.1007/s11011-021-00812-6

Cited by 5 publications

(1 citation statement)

References 66 publications

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“…kaygı ve anksiyete benzeri bir profil sergiledikleri tespit edilmiştir. Aynı sıçanlar (lezzetli yiyecekleri taklit etmek amaçlı) sakkaroz tükettiklerinde kaygı davranışlarını azalttıkları gözlenmiştir (37).…”

Section: Hakemlik Süreciunclassified

An Easy Way to Evaluate the Female Genital Canal in Mice and Rats: Vaginal Cytology

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Metin

2022

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Dişi genital kanalın durumunu izlemek için kullanılan vajinal sitoloji yöntemi, zaman içinde farklı metodlar ortaya çıksa da, kolay ve pratik olması nedeniyle sıklıkla tercih edilmektedir. 1917’de Stockard ve Papanicolaou’nun kobay vajinal lümen epitel hücrelerinin ovulasyon döngüsünün durumuna göre değişiklik gösterdiğini keşfetmelerinin ardından östrus siklusu takibi, dişi genital sistem çalışmalarının vazgeçilmez bir parçası olmuştur. Vajinal sitolojiyi göstermek için smear örneklerinin alınma zamanı ve yöntemi, uygulayıcının tecrübesi gibi çeşitli faktörler sonuçların doğruluğu üzerine etkilidir. Östrus siklusu, sıçan ve farelerde temel olarak dört faz gösterir: proöstrus, östrus, metöstrus ve diöstrus. Her fazın hücre tipi ve yoğunluğu farklıdır. Bu derlemede; fare ve sıçandan smear alma yöntemleri ve östrus siklus fazlarının özelliklerinin yanı sıra, elde edilen verilerin deneysel çalışmalarda kullanım alanlarına yönelik literatür bilgileri yer almaktadır. Ayrıca bu çalışma, dişi üreme sistemindeki dinamik değişikliklerin takibi, deneysel çalışmaların doğru planlanması ve sonuçların değerlendirilmesi yönünden dikkat edilmesi gereken noktaları belirtmesi ile dişi deneklerle çalışacak araştırmacılara kapsamlı bir bakış açısı sağlamayı hedeflemektedir.

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Section: Hakemlik Süreciunclassified

An Easy Way to Evaluate the Female Genital Canal in Mice and Rats: Vaginal Cytology

YURTGEZEN>

ERÇETİN>

Metin

2022

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Serum concentrations of BDNF in adolescents with metabolic syndrome: a case-control study between normal - BMI adolescents and adolescents with obesity

Bacopoulou,

Angelopoulos,

Papadodima

et al. 2023

Eur J Pediatr

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Brain-Derived Neurotrophic Factor (BDNF) has been linked to various conditions of the cardiovascular and nervous systems. Scarce data exist about the concentrations of BDNF in children and adolescents in relation with obesity and metabolic syndrome (MetS). The aim of this study was to examine the serum BDNF concentrations in adolescents with metabolic syndrome and according to their body mass index (BMI) status. This was a case-control study, assessing BDNF concentrations between adolescents with MetS (with obesity vs. normal-BMI), in relation to sex, anthropometric, metabolic and endocrine parameters. Participants included male and female adolescents, whose anthropometric and metabolic panel, as well as serum BDNF concentrations were measured. A total of 59 adolescents (obesity: 29; normal-BMI: 30) were included in the study. Increased serum BDNF concentrations were observed in MetS adolescents with obesity when compared with normal-BMI adolescents (p < 0.001). Males exhibited higher concentrations of BDNF than females (p = 0.045). The sample was further divided into four categories by sex and BMI status, with normal-BMI females exhibiting significantly lower BDNF concentrations than females and males with obesity(p = 0.005). In the entire study sample, serum BDNF concentrations correlated positively with BMI z-scores, however, this statistical significance was preserved only in the females of the sample. No statistical difference was observed between males of different BMI z-scores categories. Conclusion: Obesity appeared as a major factor for increased serum BDNF concentrations in adolescents with MetS (vs. normal-BMI), with a higher impact on BDNF concentrations in females than males. What is Known:• The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome in adults but data in adolescents are scarce. What is New:• Obesity (vs. normal BMI) was a major factor for increased serum BDNF in adolescents with metabolic syndrome.• Obesity had a higher impact on BDNF concentrations in females than males with metabolic syndrome.

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Adolescent exposure to a solid high-fat, high-sugar ‘cafeteria’ diet leads to more pronounced changes in metabolic measures and gut microbiome composition than liquid sugar in female rats

et al. 2022

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Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner

Cited by 5 publications

References 66 publications

An Easy Way to Evaluate the Female Genital Canal in Mice and Rats: Vaginal Cytology

An Easy Way to Evaluate the Female Genital Canal in Mice and Rats: Vaginal Cytology

Serum concentrations of BDNF in adolescents with metabolic syndrome: a case-control study between normal - BMI adolescents and adolescents with obesity

Adolescent exposure to a solid high-fat, high-sugar ‘cafeteria’ diet leads to more pronounced changes in metabolic measures and gut microbiome composition than liquid sugar in female rats

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