Paleocerebellar electrical stimulationinduces the reduction of seizures and the development of absence epilepsy in rats with penicillin- induced epilepsy

Godlevsky, L. S.; Polyasny, V. A.; Luijtelaar, E.L.J.M. van; Coenen, Antony M L

doi:10.5835/jecm.omu.29.01.012

Cited by 3 publications

(2 citation statements)

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“…Such type of evolution did not take place in our observations but provoked with paleocerebellar ES. Obtained results correspond with the data on the precipitation of SWD (3/sec) in the rat brain cortex on the focal penicillin-induced foci model caused by paleocerebellar ES [47]. They correspond also with the theory on the leading cortical role in SWD generation [9, 46] and with the general conception on the role of GABA-ergic mechanisms in SWD precipitation.…”

Section: Discussionsupporting

confidence: 83%

“…Hence, it might be supposed that influences coming to the forebrain from stimulated paleocerebellum can precipitate EEG signs of AS in the cortical GABA-A mechanism zone disturbed with local penicillin application. This effect of ES is promoted by the increase of GABA-ergic inhibition in target neuronal chains as far as investigated components of seizure discharged (slow wave, PPC) reflect the heightened state of GABA inhibition and developed in parallel with the suppression of spike discharges [43, 47, 48].…”

Section: Discussionmentioning

confidence: 99%

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Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

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The new aggregate data analyses revealed the earlier missing role played by the cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation. Therefore the appearance of prolonged periods of SWD is regarded as a tonic cerebellar influence upon pacemaker of SWD and might be caused by the long-lasting DBS-induced increase of GABA-ergic extrasynaptic inhibition in forebrain networks. At the same time, cerebellar DBS high-frequency (100 Hz) suppressed bursts of SWD observed during the phase of stimulation. Different types of cerebellar DBS upon epileptic activity emphasized the absence seizure facilitation discussed with the reviewed data on optogenetic stimulation, neuronal activity of cerebellar structures, and functional magnetic resonance imaging data.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

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Cerebellar contribution to absence epilepsy

Akyüz

Ozenen

Pinyazhko

et al. 2021

Neuroscience Letters

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Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ

Godlevsky

Pervak

Poshyvak

et al. 2022

Preprint

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Background In recent years, the cerebellum and its nuclei have become important targets for understanding and suppressing the mechanisms of seizures. The aim of this study was to investigate the effects of electrical stimulation (ES) applied to the lateral cerebellar nucleus (LCN) in rats with early and fully developed pentylenetetrazol (PTZ)-kindled seizures. MethodsThe experimental groups were represented by rats kindled with PTZ (35.0 mg/kg, i.p.) to myoclonus (9-11 PTZ injections) and generalized tonic-clonic seizures (21 PTZ injections). Unilateral ES (100 Hz, 0.25 ms, 4.5-5.0 duration) was delivered daily for five days after the last kindled PTZ administration with PTZ seizure testing after the last ES. Results ES of LCN performed at the early stage of kindling facilitated the appearance of myoclonus and increased seizure severity by 30.2% - up to 2.25+0.46 scored points compared to the control group (P<0.05). In fully developed kindling, ES prevented generalized seizure and reduced seizure severity by 27.5% - to 3.11+0.31 scored points (P<0.02). In both groups,spikes in the frontal and ventral hippocampus corresponding to myoclonuswere noticed. The linear density of PC in the cerebellar hemisphere cortex was reduced to 9.67±1.12in fully kindled rats, while in the control group, it was 20.17±2.10 per mm (P<0.05). Conclusion The data obtained showed that repeated ES of the LCN at the early kindling stage facilitates myoclonus appearance, while in fully PTZ-kindled rats causes suppression of generalized seizure fits, which were substituted with myoclonus.

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Paleocerebellar electrical stimulationinduces the reduction of seizures and the development of absence epilepsy in rats with penicillin- induced epilepsy

Cited by 3 publications

References 34 publications

Cerebellar Contribution to Absence Epilepsy

Cerebellar Contribution to Absence Epilepsy

Cerebellar contribution to absence epilepsy

Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ

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