Palladium and Platinum

Chaloner, Penny A.

doi:10.1016/0010-8545(86)80029-7

Cited by 15 publications

(6 citation statements)

References 510 publications

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“…Therefore, the other coordination of the ligand to the metal should be through the terminal amino groups with the amide group in the side chain free, thus behaving like a simple amino acid, i.e. glycine 2, alanine. Any other mode of binding (i.e.…”

Section: Mechanism and Conclusionmentioning

confidence: 99%

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Kinetics of substitution of aqua ligands from cis‐diaqua (ethylenediamine)platinum(II) perchlorate by L‐asparagine in aqueous medium

Bera

Chandra

2003

Int J of Chemical Kinetics

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The kinetics of the interaction of L-asparagine with [Pt(ethylenediamine) [L-asparagine], and temperature at pH 4.0, where the substrate complex exists predominantly as the diaqua species and L-asparagine as the zwitterion. The substitution reaction shows two consecutive steps: the first step is the ligand-assisted anation and the second one is the chelation step. Activation parameters for both the steps have been calculated using Eyring equation.

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Section: Mechanism and Conclusionmentioning

confidence: 99%

“…Substitution reactions on square planar platinum(II) complexes have attracted continued attention because of their intrinsic chemical 1–4 and biomedical applications 5–7. In particular cis ‐platin 8–13, [ cis ‐dichlorodiamineplatinum(II)], and its structural analogues 14 have been used in cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of substitution of aqua ligands from cis‐diaqua (ethylenediamine)platinum(II) perchlorate by L‐asparagine in aqueous medium

Bera

Chandra

2003

Int J of Chemical Kinetics

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“…15 These metals and their complexes are also useful as catalysts. 16 The complexes of palladium(II) with amino acids such as glycine, serine and glutamine have been reported to be active against certain tumours. 17 It is a well-established fact that carcinostatic action of drugs is due to their interaction with nuclear DNA.…”

Section: Introductionmentioning

confidence: 99%

Biologically Potent Azomethine Complexes of Palladium(II) and Platinum(II)

Biyala

Sharma

Fahmi

et al. 2007

Phosphorus, Sulfur, and Silicon and the Related Elements

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The sulfur-nitrogen donor ligand, 1-acetylferrocenehydrazinecarbothioamide (L 1 H) and oxygen-nitrogen donor ligand, 1-acetylferrocenehydrazinecarboxamide (L 2 H) have been synthesized by condensation of 1-acetylferrocene with corresponding hydrazinecarbothioamide and hydrazinecarboxamide, respectively. The structure determination of palladium(II) and platinum(II) complexes was performed by elemental analysis, melting point determinations, conductivity measurements, molecular weight determinations, IR, 1 H NMR and UV spectral studies. Based on these studies the square planar environment around the metal atoms has been proposed. Studies were also conducted to assess the comparative growth-inhibiting potential of the synthesized complexes and the azomethines against a variety of fungal and bacterial strains.

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“…Ligand substitution at square planer platinum complexes is one of the most throughly investigated reactions in inorganic chemistry due to their intrinsic chemical [1][2][3] and biomedical applications [4][5][6]. The search of novel platinum and other metal based drugs wider clinical applications [8] though the aqua variety was found to be superior to others [10].…”

Section: Introductionmentioning

confidence: 99%

Substitution of aqua ligands from ds-[Pt(en)(H2O)2](ClO4)2 and cis-[Pt(dmen)(H2O)2](ClO4)2 (en = ethylenediamine, dmen = Ν,Ν′-dimethylethylenediamine) by glutathione (reduced) (GSH) in aqueous medium - A Kinetic And Mechanistic Study.

Bera¹,

Sengupta²,

De³

2003

BioInorganic Reaction Mechanisms

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The kinetics of the interaction of glutathione (reduced) (GSH) with [Pt(en)(H 2 0)2](C10 4 )2and [Pt(dmen)(H 2 0) 2 ](C104) 2 (en = ethylenediamine, dmen = N,N'-dimethylethylenediamine) have been studied spectrophotometrically as a function of [substrate complex], [glutathione] and temperature at a particular pH (4.0). The reaction was found to proceed via rapid outersphere association complex formation followed by two slow consecutive steps. The first step involves the transformation of the outersphere complex into the innersphere complex containing Pt-S bond, while the second step involves chelation when the second aqua ligand is displaced. The association equlibrium constant (K E ) and the two rate constants k, and k 2 have been evaluated. Activation parameters for both the steps have been calculated using Eyring equation. The low enthalpy of activation and large negative values of entropy of activation indicate an associative mode of activation for both steps.

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Palladium and Platinum

Cited by 15 publications

References 510 publications

Kinetics of substitution of aqua ligands from cis‐diaqua (ethylenediamine)platinum(II) perchlorate by L‐asparagine in aqueous medium

Kinetics of substitution of aqua ligands from cis‐diaqua (ethylenediamine)platinum(II) perchlorate by L‐asparagine in aqueous medium

Biologically Potent Azomethine Complexes of Palladium(II) and Platinum(II)

Substitution of aqua ligands from ds-[Pt(en)(H2O)2](ClO4)2 and cis-[Pt(dmen)(H2O)2](ClO4)2 (en = ethylenediamine, dmen = Ν,Ν′-dimethylethylenediamine) by glutathione (reduced) (GSH) in aqueous medium - A Kinetic And Mechanistic Study.

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