Palladium-Catalyzed Reactions

Abstract

Palladium is probably the most versatile and exploited transition metal in catalysis due to its capability to promote a myriad of organic transformations both at laboratory and industrial scales (alkylation, arylation, cyclization, hydrogenation, oxidation, isomerization, cross-coupling, cascade, radical reactions, etc [...]

Actual Process Impurity or an Analytical Artifact? A Case Study Involving Conversion of Amide to Nitrile to Uncover the Truth and Mitigate

“…In pharmaceutical product development, catalysis plays a vital role and remains part of multiple steps in a sequence of chemical reactions. 7 Since palladium demonstrates predictable and controllable catalytic properties, it is widely used for various applications in several organic transformations, such as alkylation, arylation, cyclization, hydrogenation, oxidation, isomerization, cross-coupling, cascade, radical reactions, etc. 8 Nonetheless, achieving the complete removal of these metal impurities from the final product proves to be a laborious and time-consuming task.…”

Enhanced Activity of MOF-Based Pd/Electron-Transfer Mediator Catalysts in Oxidation Reactions Involving Isonitrile by Defect Engineering

“…Palladium-catalyzed aerobic oxidation serves as the foundation for transforming simple feedstocks into high-value products. For instance, Pd(II)-catalyzed aerobic oxidation involving isonitrile CN bonds is a convenient and concise strategy for the construction of functionalized N -containing skeletons . Despite extensive research in this area, the challenge of achieving high catalytic efficiency persists due to palladium inactivation.…”