Palladium(II) complexes with 5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione

Bakalova, Adriana; Varbanov, Hristo P.; Buyukliev, Rossen; Momekov, Georgi; Ivanov, D.

doi:10.1007/s10973-007-8937-3

Cited by 20 publications

(14 citation statements)

References 27 publications

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“…The presence of two bands, assigned for PdHal stretching vibrations proved the cis-geometry of the complexes. This data is in good correlation with our previously described data for Pd(II) complexes with MPH [15].…”

Section: Chemistrysupporting

confidence: 92%

“…The new compounds were tested for cytotoxic activity in vitro on various human tumor cell lines. We also conducted qualitative antimicrobial assays on three pathogenic microorganisms in comparison with our previously described palladium complexes incorporating 5-methyl-5-(4-pyridyl)hydantoin (MPH) [15] and their platinum analogues with MPH [16] and AMPH [17].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of palladium(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin: cytotoxic and antimicrobial investigations and comparison with their platinum analogues

Varbanov

Bakalova

Buyukliev

et al. 2010

Transition Met Chem

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Two new Pd(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin (AMPH) were synthesized: cis-[Pd(AMPH) 2 Cl 2 ]Á2H 2 O and cis-[Pd(AMPH) 2 Br 2 ]ÁH 2 O. The complexes were characterized by physico-chemical and spectroscopic methods. The determination of crystal water content in the complexes was defined by Karl Fisher titration. The cytotoxic effects of these complexes were examined on a panel of human tumor cell lines. Qualitative antimicrobial assays on three pathogenic microorganisms of the new complexes, their analogues with 5-methyl-5-(4-pyridyl)-hydantoin(MPH) and their platinum analogues were made. Cis-[Pd(mpyh) 2 Br 2 ]ÁH 2 O showed significant activity against C. albicans.

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Section: Chemistrysupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Synthesis of palladium(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin: cytotoxic and antimicrobial investigations and comparison with their platinum analogues

Varbanov

Bakalova

Buyukliev

et al. 2010

Transition Met Chem

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“…1. The structures are confirmed by the IR and NMR spectra of the new compounds and are in accordance with previously synthesized by us complexes [4][5][6][7]. A. Bakalova et al…”

supporting

confidence: 86%

“…The newly four synthesized and tested complexes were added to 12 previously evaluated compounds [4][5][6][7] and a set of 16 similar compounds was compiled. Free-Wilson model was derived by PLS and the contribution of each substituent was assessed quantitatively.…”

Section: Qsar Methods Qsarmentioning

confidence: 99%

“…Data from the elemental analysis, IR, NMR spectral analysis and molar conductivity demonstrated the coordination mode of the ligands with metal ions. In all complexes the ligand was coordinated monodentatelly with M 2þ and Pt 4þ via N-atom from the pyridine ring [4][5][6][7]. The present study represents the synthesis and physicochemical evaluation of four new Pt(II) and Pt(IV) complexes with 3,5-dimethyl-5-(4-pyridyl)hydantoin (L) and 5-methyl-5-(4-pyridyl)hydantoin (L 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Platinum Complexes with 5‐Methyl‐5(4‐pyridyl)hydantoin and Its 3‐Methyl Derivatives: Synthesis and Cytotoxic Activity – Quantitative Structure‐Activity Relationships

Bakalova

Varbanov

Buyukliev

et al. 2010

Archiv der Pharmazie

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3,5-Dimethyl-5-(4-pyridyl)hydantoin (L) and its platinum(II) and platinum(IV) complexes with the general formula cis-[PtL(2) X(2) ] · n H(2) O and [PtL(2) Cl(4) ], where XCl, I and n = 2-4 were synthesized. A new Pt(IV) complex with 5-methyl-5-(4-pyridyl)hydantoin (L') with the formula cis-[Pt(L')(2) Cl(2) (OH)(2) ] · 5 H(2) O was also synthesized. The novel compounds were characterized by elemental analysis, IR, (1) H-, (13) C-, (195) Pt-NMR spectra and molar conductivity. The cytotoxic effects of these complexes were examined on three human tumor cell lines by MTT-dye reduction assay. These four new Pt(II) and Pt(IV) complexes and a set of another twelve Pt(II), Pt(IV), and Pd(II) complexes previously synthesized and tested were compiled and a QSAR model was derived in order to direct the further rational synthesis.

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Some tetrazolium salts and their ion-association complexes with the molybdenum(VI) — 4-nitrocatechol anionic chelate

Gavazov

Lekova

Boyanov

et al. 2009

J Therm Anal Calorim

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Palladium(II) complexes with 5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione

Cited by 20 publications

References 27 publications

Synthesis of palladium(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin: cytotoxic and antimicrobial investigations and comparison with their platinum analogues

Synthesis of palladium(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin: cytotoxic and antimicrobial investigations and comparison with their platinum analogues

Platinum Complexes with 5‐Methyl‐5(4‐pyridyl)hydantoin and Its 3‐Methyl Derivatives: Synthesis and Cytotoxic Activity – Quantitative Structure‐Activity Relationships

Some tetrazolium salts and their ion-association complexes with the molybdenum(VI) — 4-nitrocatechol anionic chelate

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