Palladium Iodide Catalyzed Multicomponent Carbonylative Synthesis of 2-(4-Acylfuran-2-yl)acetamides

Ziccarelli, Ida; Veltri, Lucia; Prestia, Tommaso; Amuso, Roberta; Chiacchio, Maria A.; Mancuso, Raffaella; Gabriele, Bartolo

doi:10.3390/molecules28196764

Cited by 2 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis. [35][36][37][38][39][40] Several authors have recently reviewed the cyclo-carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members. [41][42][43][44][45][46][47][48][49][50] This section explained the synthesis of α, βalkynyl ketones, coumarin, 2-quinolone, indol derivative, furane derivative, and chromenone heterocyclic compound from homogenous palladium-catalyzed carbonylation reaction.…”

Section: Synthesis Of Heterocyclic Compoundsmentioning

confidence: 99%

“…Oxidative carbonylation with PdI 2 (1 mol %)/KI(100 mol %) catalytic system gives 2-(4-acylfuran-2-yl) acetamides in fair to good yields (54-81 %). [38] They were the first to report the 2-(4-acylfuran-2-yl) acetamide as a product of carbonylation. The mechanistic pathway involving C sp À H activation of the substrate by oxidative monoaminocarbonylation leads to the formation of 2-ynamide intermediates.…”

Section: By Using Co Cylindermentioning

confidence: 99%

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis [35–40] . Several authors have recently reviewed the cyclo‐carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members [41–50] .…”

Section: Catalytic Carbonylation Via Homogeneous Catalytic Routementioning

confidence: 99%

“…For 15 h, they preceded the reaction with 2‐propargyl‐1, 3‐dicarbonyl compounds, CO, and NR 2 H at 100 °C. Oxidative carbonylation with PdI 2 (1 mol %)/KI(100 mol %) catalytic system gives 2‐(4‐acylfuran‐2‐yl) acetamides in fair to good yields (54–81 %) [38] . They were the first to report the 2‐(4‐acylfuran‐2‐yl) acetamide as a product of carbonylation.…”

Section: Catalytic Carbonylation Via Homogeneous Catalytic Routementioning

confidence: 99%

See 3 more Smart Citations

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

Pant,

Prakash,

Dhami

2024

ChemistrySelect

View full text Add to dashboard Cite

Catalytic carbonylation has gained a lot of interest over the past 20 years. It produced various pharmaceuticals, agrochemicals, and intermediates that can made through this process. The carbonylation process is the most straightforward method to insert CO into any organic substrate using a simple carbonyl source, i. e., CO gas. Apart from gaseous CO, many techniques have devised for producing CO in situ using surrogates such as HCOOH, DMF, Formic acid, Phenyl Formate, Oxalic acid, and Chloroform. Several carbonylation methods, such as aminocarbonylation, alkoxycarbonylation, double carbonylation, and oxidative carbonylation, provide viable and appealing substitutes for conventional synthetic methods on a commercial or laboratory scale. Many recent studies focus on catalyst‐product separation, catalyst recoverability, and reusability in these reactions. Therefore, advancements in using different approaches, such as supported liquid phase catalysis and biphasic catalysis, to anchor homogeneous catalysts are becoming increasingly important. These carbonylation methods are easy to use, cost‐effective, and do not require ligands. They also produce excellent yields of the products necessary. Using phosphine ligands has drawbacks, including high work‐up costs, laborious work‐up techniques, and sensitivity to air and moisture. Several phosphine‐free carbonylation pathways offer affordable and straightforward ways to accomplish these changes without phosphine ligands. This review summarizes the synthetic application of homogeneous and immobilized catalysts in producing carboxylic acid derivatives and heterocycles that have medicinal properties.

show abstract