2004
DOI: 10.1093/annonc/mdh422
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Palliative chemotherapy for advanced gastric cancer

Abstract: Analysis of results shows chemotherapy to be superior to best supportive care alone. Combination chemotherapy compared with monochemotherapy is associated with significantly higher overall (complete plus partial) response rates but nevertheless results in similar survival. ECF (epirubicin, cisplatin and 5-fluorouracil) currently represents one of the most effective regimens for advanced gastric cancer, whereas among the newer combinations, irinotecan- or taxane-based regimens have also given promising results.… Show more

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Cited by 158 publications
(127 citation statements)
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References 90 publications
(81 reference statements)
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“…The survival time for gastric cancer patients receiving the best supportive care is 3-5 months. In addition, although tumor reduction was observed in only one patient, these results are not inferior compared with those of reports of secondline chemotherapy for advanced gastric cancer [23][24][25]. The CTL response was significantly stronger in four patients, with the resulting prognosis also being longer than in the remaining two patients.…”
Section: Discussioncontrasting
confidence: 50%
“…The survival time for gastric cancer patients receiving the best supportive care is 3-5 months. In addition, although tumor reduction was observed in only one patient, these results are not inferior compared with those of reports of secondline chemotherapy for advanced gastric cancer [23][24][25]. The CTL response was significantly stronger in four patients, with the resulting prognosis also being longer than in the remaining two patients.…”
Section: Discussioncontrasting
confidence: 50%
“…Cytotoxic chemotherapy including 5-fluorouracil (5-FU) is the most effective means of providing survival benefits and improvements in quality of life compared with best supportive care (Wöhrer et al, 2004). However, these improvements have been modest, at best, and thus far no combination has clearly provided a survival advantage over single agent 5-FU (Ohtsu, 2005).…”
mentioning
confidence: 99%
“…In advanced gastroesophageal cancer, irinotecan has been studied in phase II trials as a single agent and in combination with various other agents, including FU and cisplatin. Single-agent response rates are around 20%, although rates of up to 60% have been reported for irinotecan combined with cisplatin (Kohne et al, 2003;Wohrer et al, 2004).…”
mentioning
confidence: 99%