Palliative Surgery for Rare Cases of Anterior Urethral Metastasis in Prostate Cancer

Gómez, Enrique Gómez; Aznar, José; Rodríguez, M.; Rosa, José Valero; Tapia, María José

doi:10.1155/2014/584957

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…They also reported that 41% of patients had died of cancer within 6 months after diagnosis 12 . However, to the best of our knowledge, patients with urethral metastasis from prostate cancer that have been reported since 2000 had better prognosis: only two patients died within 2 years after diagnosis 1–9 . Compared with penile metastasis, urethral metastasis is more likely to cause hematuria and lower urinary tract symptoms, which may lead to early detection and treatment.…”

Section: Discussionmentioning

confidence: 97%

“…Treatment of metastatic prostate cancer to the urethra remains controversial. Most patients underwent ADT with or without transurethral resection, 2,3,6–9 and some cases of prostate cancer metastasizing to the urethra during ADT were treated with chemotherapy 1,4 . Cases of recurrent urethral tumors after achieving remission with ADT have been also reported, and urethrectomy and CyberKnife radiotherapy were performed with good outcomes 3,6 .…”

Section: Discussionmentioning

confidence: 99%

“…Common sites of metastases from prostate cancer comprise the bones, distal lymph nodes, liver, and lung. Regarding metastatic penile cancer, it occurs more frequently in the corpus cavernous or foreskin than in the urethra 3 . Herein, we describe the case of metastatic prostate cancer to the anterior urethra.…”

Section: Introductionmentioning

confidence: 97%

“…Metastatic urethral tumors usually originate from the bladder. Metastatic prostate cancer to the urethra is rare and only 11 previous cases after 2000 have been reported 1–9 . Common sites of metastases from prostate cancer comprise the bones, distal lymph nodes, liver, and lung.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Fujiwara¹,

Ishida²,

Arai

et al. 2021

IJU Case Reports

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Introduction Primary or metastatic urethral tumors are extremely rare. However, treatment strategies differ between primary and metastatic tumors. Therefore, establishing an accurate diagnosis is critically needed for initiating timely and appropriate therapy. Case presentation We describe the case of a 79‐year‐old man with prostate cancer treated with radiotherapy and androgen deprivation therapy. He presented with macroscopic hematuria as a symptom of anterior urethral tumor at follow‐up. Endoscopic tumor resection was performed. Hematoxylin and eosin staining showed adenocarcinoma component. Immunohistochemical staining revealed presence of metastatic prostate cancer to the urethra. Conclusion Regarding urethral tumors diagnosis, urologists should consider the possibility of metastasis from prostate cancer and perform immunohistochemical examination for establishing accurate diagnosis. Furthermore, if androgen deprivation therapy fails to suppress symptoms, radiotherapy or urethrectomy might be considered.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Fujiwara¹,

Ishida²,

Arai

et al. 2021

IJU Case Reports

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Primary resection of oligometastatic recurrent prostatic carcinoma in the urethra

Foo

Lim²,

Cheng³

et al. 2022

BMJ Case Rep

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A man in his 70s presented to the emergency department with acute urinary retention following a 2-day history of gross haematuria with blood clots. He had a significant medical history of intermediate-risk prostate adenocarcinoma (grade group 2, prostate-specific antigen (PSA) 14.9 ng/mL) for which he underwent a robotic-assisted laparoscopic radical prostatectomy (RARP) 13 years ago. PSA nadir was achieved (<0.03 ng/mL). Three years after RARP, he had biochemical recurrence with PSA rising to 0.06 ng/mL. Salvage radiotherapy was performed with good PSA response back to nadir. Workup for gross haematuria included a flexible cystoscopy which revealed a lobulated fleshy lesion occupying the mid-penile urethra. Staging imaging showed no local recurrence at prostatectomy site or lymphadenopathy. PSA was 4.2 ng/mL. Surgical resection with primary repair of the urethra was performed. Postoperative recovery was good with PSA achieving nadir. Histology revealed an upgraded metastatic prostate adenocarcinoma, grade group 5.

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Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review

et al. 2022

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Background Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. Case presentation In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. Conclusion These are the first reports of two cases of urinary tract metastasis of AIPC.

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Palliative Surgery for Rare Cases of Anterior Urethral Metastasis in Prostate Cancer

Cited by 3 publications

References 14 publications

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Isolated recurrence of prostate cancer to the anterior urethra 5 years after radiation therapy

Primary resection of oligometastatic recurrent prostatic carcinoma in the urethra

Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review

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