Palmar dermatoglyphic traits in type 2 diabetes  mellitus patients of Bengalee Hindu caste population  of West Bengal, India: a cross-sectional study

Ghosh, Jyoti Ratan; Dastidar, P.; Dey, Biswarup; Das, Piyali; Bandyopadhyay, Arup Ratan

doi:10.3126/jbs.v3i2.18919

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Apart from the efficacy of insulin and several oral hypoglycemic drugs used for the treatment of diabetes mellitus, they still have a number of side effects. Management of this metabolic disorder has a number of challenges for both patients and physicians 41. Investigations have revealed that traditional herbal medicines offer exciting opportunities, such as unlimited resources for the discovery of new drugs that can be used for the welfare of mankind.…”

Section: Discussionmentioning

confidence: 99%

<p>In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model</p>

Malik

Jamil

Butt³

et al. 2019

DDDT

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Background: In silico characterization can help to explain the interaction between molecules and predict three-dimensional structures. Various studies have confirmed the glucose-lowering effects of plant extracts, ie, lupeol and iso-orientin, which enable them to be used as antidiabetic agents. Purpose: Aims of the present study were to evaluate the hypoglycemic activities of lupeol and iso-orientin in a rat model. The study proposed the effects of alloxan on blood glucose level, body weight, and oxidative stress. Materials and Methods: Thirty (n=30) Wistar albino rats were divided into six groups and were subjected to different combinations of the compounds. Levels of different stress markers, ie, malondialdehyde, superoxide dismutase, catalase, nitric oxide, glutathione, glutathione peroxide, glutathione reductase, and blood glucose levels were estimated with their respective methods. Whereas, for their in silico analysis, identified target proteins, GPR40, glucose-6-phosphatase, UCP2, glycogen phosphorylase, aldose reductase, and glucose transporter-4 were docked with lupeol and iso-orientin. Three-dimensional structures were predicted by ERRAT, Rampage, Verify3D, threading and homology approaches. Results: Blood glucose levels were significantly increased in rats receiving intraperitoneal injection of alloxan (208±6.94 mg/dL) as compared to controls (90±7.38 mg/dL). Infected rats were administered plant extracts; combined treatment of both extracts (lupeol+iso-orientin) significantly reduced the levels of blood glucose (129.06±6.29 mg/dL) and improved the antioxidant status. Fifteen structures of each selected protein were evaluated using various techniques. Consequently, satisfactory quality factors [GPR40 (96.41%), glucose-6-phosphatase (96.56%), UCP2 (72.56%), glycogen phosphorylase (87.24%), aldose reductase (82.46%), and glucose transporter-4 (94.29%)] were selected. Molecular docking revealed interacting residues, effective drug properties and their binding affinities (ie, −8.9 to −12.6 Kcal/mol). Conclusion: Results of the study affirmed the antidiabetic activities of lupeol and iso-orientin. Administration of these extracts (either individually or in combination) significantly reduced blood glucose levels and oxidative stress. Hence, it may be considered beneficial in the treatment of diabetes.

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Section: Discussionmentioning

confidence: 99%

<p>In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model</p>

Malik

Jamil

Butt³

et al. 2019

DDDT

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Intelligent Framework for Early Prediction of Type – II Diabetes by Accelerating Palm Print Images using Graph Data Science

Rai,

Pakkala

et al. 2023

2023 IEEE International Conference on Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER)

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Measurement of the Atd Angle in the Patient of Diabetics Mellitus: A Reliable Marker.

Dixit

Modi

2022

ijsr

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Background: DM has been shown to be associated with certain dermatoglyphic traits and Indians in particular have been shown to be predisposed to DM. It can be used for early and inexpensive screening of individuals at risk for DM. Aim of present study was to measure the atdangle in the patient of Diabetics Mellitus and compare it with control. The present comparative case control study was conducted in theMaterial & Methods: Department of Medicine, Saraswati Medical College&Hospital, Unnao.100clinically diagnosed diabetic patients in study group werecompared with same age group of 100 non- diabetic patients. Patients with deformity of hand, Chromosomal abnormalities like Klinefelter's syndrome, Turner's syndrome etc. and diseases like congenital anomalies, neurological disorders, carcinomas and psychiatric diseases were excluded from the study. The mean atd angles were signicantly lower in DM group and mean dat angles were signicantly higher in DM groupObservation: than controls whereas adt angles were signicantly higher in left and signicantly lower in right of the DM group (p<0.05). It was noted thatmean atd angles in both male and femaleparticipant was signicantly lower in DM group in both hand and mean dat angles were signicantly higher in DM than controls group; whereas adt angles in both male and female participants were higher signicantly in left and insignicantly lower in right of the DM group (p<0.05). The mean Atd angles were signicantly decreased in DM group, angle 'Adt' showed signicant increase inConclusion: left hand and mean dat angles were signicantly increased in both hands of the cases as compared to controls.

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Palmar dermatoglyphic traits in type 2 diabetes mellitus patients of Bengalee Hindu caste population of West Bengal, India: a cross-sectional study

Cited by 4 publications

References 18 publications

<p>In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model</p>

<p>In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model</p>

Intelligent Framework for Early Prediction of Type – II Diabetes by Accelerating Palm Print Images using Graph Data Science

Measurement of the Atd Angle in the Patient of Diabetics Mellitus: A Reliable Marker.

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