Palmoplantar pustules and osteoarticular pain in a 42-year-old woman

Zuo, Rena C.; Schwartz, Daniella M.; Lee, Chyi‐Chia Richard; Anadkat, Milan J.; Cowen, Edward W.; Naik, Haley B.

doi:10.1016/j.jaad.2014.07.014

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…Inflammatory cutaneous and articular manifestations have been found among SAPHO syndrome patients 23 . The main characteristics of the dermatologic manifestations are neutrophilic pustular dermatoses, 24 including pustular psoriasis, palm plant impetigo (PPP), psoriasis vulgaris, severe acne, or hidradenitis suppurativa 9,25,26 . Chronic inflammatory aseptic osteitis is the central feature of SAPHO bone lesions, manifested by tenderness, pain, and changes in bone structure 7,27 .…”

Section: Discussionmentioning

confidence: 99%

An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

Wang,

Gong,

Xia

et al. 2024

Int J of Rheum Dis

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BackgroundSAPHO syndrome is recognized as a rare entity with damage to skin and bones due to inflammation. Currently, the treatment for SAPHO syndrome is still a challenge in clinical practice. In this study, an integrated transcriptomics and network pharmacology approach was applied to explore the therapeutic effect and mechanism of Wang‐Bi tablet (WBT) on SAPHO syndrome.MethodsThe main components of WBT and their targets, as well as the targets of SAPHO syndrome, were collected from databases. Network visualization was performed using Cytoscape software. The GO and KEGG enrichment analysis was executed by David dataset. Then, the molecular mechanism of WBT improving SAPHO syndrome was validated by transcriptomics of peripheral blood neutrophils in SAPHO syndrome. Finally, the above results were validated by molecular docking.ResultsThe Network Pharmacology results showed there are 152 core targets for WBT treatment on SAPHO syndrome. RNA‐seq data showed 442 differentially expressed genes (DEGs) in peripheral blood neutrophils of SAPHO patients. Intriguingly, NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway were included in the enrichment results of network pharmacology and RNA‐seq. Moreover, we verified that the core components of WBT have good affinity with the core targets of NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway by molecular docking.ConclusionsThis study illustrated that the possible mechanisms of WBT against SAPHO syndrome may be related to NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway, and further experiments are needed to prove these predictions.

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Section: Discussionmentioning

confidence: 99%

An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang‐Bi tablet against SAPHO syndrome

Wang,

Gong,

Xia

et al. 2024

Int J of Rheum Dis

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“…Severe acne, specifically acne conglobata and acne fulminans, present in about 25% of patients [6]. PPP are detected in 50-75% of the SAPHO patients [10]. The musculoskeletal symptoms can occur before skin involvement in 40-68%, 30% simultaneously and late manifestation in 32-60% of patients [7].…”

Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome: A Chameleon in Medical Diseases

2015

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SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a unique condition. Its rarity and variable presentation consummate its place within an elite group of elusory diagnosis. As a result, the diagnosis of SAPHO syndrome is often delayed by many years and is associated with increased medical cost, human suffering and worsened outcome. We present an atypical presentation of the SAPHO syndrome exhibiting an insidious onset of left hip pain with proximal femoral diaphyseal sterile osteitis along with severe weight loss that remained undiagnosed for over 5 years. We searched PubMed using SAPHO syndrome, unique SAPHO, SAPHO case study, SAPHO, CMRO and diaphysis as keywords for our literature review. The purpose of this case report is to emphasize a need for vigilance, timely recognition and prompt treatment. We further recommend aggressive early therapy for swift symptom resolution and improved medical outcome.

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“…Synovitis, pustulosis, acne conglobata, hyperostosis, and osteitis are clinically speciic inlammatory disorders that may be seen barely in the same patient in a syndrome known as SAPHO syndrome [2].…”

Section: Clinical Presentationmentioning

confidence: 99%