Palpable maculopapular rash with elevated ESR: What is your diagnosis?

Chakraborty, Subhankar; DiMaio, Dominick J.; Vanschooneveld, Trevor

doi:10.3109/03009734.2013.831504

Cited by 2 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to skin lesions, leukocytoclastic vasculitis may be associated with systemic manifestations, such as abdominal and joint pains, and renal involvement. 20 …”

Section: Discussionmentioning

confidence: 99%

“…However, systemic involvement needs steroids alone or in combination with immunosuppressive drugs. 10 , 20 , 26 In general, skin-limited disease has a good prognosis, and the time to recovery is variable, ranging from days to weeks. 27 , 28 Nonetheless, around 10% of reported cases develop recurrent or chronic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to skin lesions, leukocytoclastic vasculitis may be associated with systemic manifestations, such as abdominal and joint pains, and renal involvement. 20 Detailed history, physical examination and laboratory workup are essential steps in evaluating leukocytoclastic vasculitis, focusing on the presence of underlying cause and systemic involvement. 21 The American College of Rheumatology proposed criteria to define leukocytoclastic vasculitis including patient age >16 years; use of a possible drug in temporal relation to symptoms; palpable purpura; maculopapular skin lesions; and biopsy of a skin lesion showing neutrophils around arterioles or venules.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 60 published articles were included, comprising a total of 74 cases published between 1955 and 2021 (Table 1). 20,26,27,30 –86 Analyses of the reported cases of antibiotic-induced leukocytoclastic vasculitis revealed that it is associated with numerous classes of antibiotic, including penicillin (amoxicillin, amoxicillin-clavulanic acid, oxacillin), cephalosporins (cefazolin, cephalexin, cefuroxime, ceftriaxone, cefotaxime), fluoroquinolone (ciprofloxacin, levofloxacin, ofloxacin), macrolides (azithromycin, clarithromycin), vancomycin, teicoplanin, trimethoprim-sulfamethoxazole, dapsone, linezolid, pristinamycin, tigecycline, isoniazid, streptomycin, rifampin, ethambutol, and pyrazinamide.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis

et al. 2022

View full text Add to dashboard Cite

Leukocytoclastic vasculitis (hypersensitivity vasculitis) is defined as small blood vessel inflammation with skin or other systemic manifestations due to infections, drugs, or neoplastic disease. This clinical case report highlights an association between ceftriaxone and leukocytoclastic vasculitis in a 49-year-old female patient with a history of penicillin allergy, on mirtazapine for anxiety disorder. Articles concerning antibiotic-induced leukocytoclastic vasculitis are also reviewed. The patient reported a symptom of upper respiratory tract infection and fever 5 days previously for which she received ceftriaxone for 2 days before presenting to the emergency department with a pruritic skin rash in the upper and lower extremities and swollen lips for 1 day. The rash was erythematous, maculopapular, itchy, and non-tender, with no mucus membrane involvement. Laboratory investigations revealed leukocytosis (white blood cells, 22.3 × 109/L) that was mainly eosinophilic (18.4%). The patient was administered prednisolone and antihistamine after stopping ceftriaxone empirically. A skin biopsy confirmed the diagnosis of leukocytoclastic vasculitis. Significant clinical improvement was observed after treatment initiation. Upon follow-up, the skin rash was resolved entirely with no scars; however, there was skin-peeling over the lower extremities. Recognition of antibiotic-induced leukocytoclastic vasculitis is crucial as many classes of antibiotics can contribute to this condition. Continuation of the offending drug may lead to life-threatening complications.

show abstract

“…In addition to skin lesions, leukocytoclastic vasculitis may be associated with systemic manifestations, such as abdominal and joint pains, and renal involvement. 20 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis

et al. 2022

View full text Add to dashboard Cite

show abstract

Oxacillin

2014

Reactions Weekly

View full text Add to dashboard Cite

S Oxacillin Rash in an elderly patient: case reportA 65-year-old man developed rash following treatment with oxacillin for methicillin-sensitive Staphylococcus aureus leg infection.The man was hospitalised with leg cellulitis; he was administered oxacillin [route and dosage not stated] for methicillin-sensitive Staphylococcus aureus infection followed by cefazolin. He developed a palpable rash on his back and legs [duration of treatment to reaction onset not stated]. Tests showed an ESR value of 70 mm/h with a rheumatoid factor value of 20 IU/ml. Microscopic proteinuria (protein/creatinine ratio: 0.3) and microscopic haematuria (>50 RBCs/hpf) were also reported. Histology showed a lymphocytic infiltration within the dermis.The man was diagnosed with drug rash presumably due to oxacillin. Cefazolin was continued, and he returned home after 2 weeks; at follow-up, rash resolution was noted.

show abstract

Palpable maculopapular rash with elevated ESR: What is your diagnosis?

Cited by 2 publications

References 4 publications

Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis

Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis

Oxacillin

Contact Info

Product

Resources

About