Pamidronate Therapy Increases Trabecular Bone Complexity of Mandibular Condyles in Individuals with Osteogenesis Imperfecta

Pantoja, Letícia Lopes Quirino; Lustosa, Mariana; Yamaguti, Paulo Márcio; Rosa, Lídia S; Leite, André Ferreira; Figueiredo, Paulo Tadeu de Souza; Castro, Luiz Cláudio; Acevedo, Ana Carolina

doi:10.1007/s00223-021-00915-3

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Regarding the amount of drug administered, in the study by Pantoja et al [24], they observed that there was a relationship between childhood patients who started their treatment for OI with bisphosphonates from early childhood and an improvement in the microarchitecture of the condylar bone.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies to date were performed mainly on adult patients, and there are practically no studies on pediatric patients with OI receiving bisphosphonate treatment where it was checked if there were changes in the cortical bone. Recently, studies have been published on child and adolescent patients with OI treated with bisphosphonates, such as Apolinario et al in 2015 and Pantoja et al in 2021, which highlight changes in the mandibular cortex and cortical bone after treatment with bisphosphonates [1,9,[22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Application of Orthopantomography in the Analysis of Bone Mineral Density in Patients with Osteogenesis Imperfecta

García-Boedo,

Burgueño-Torres,

de Nova-García

2024

Applied Sciences

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Osteogenesis imperfecta is a disorder characterized by osteopenia and bone fragility. Considering that orthopantomography is a routine diagnostic test in growing patients, it can be used to analyze bone density in these patients. The study sample consisted of 21 child patients diagnosed with OI, under medical treatment with antiresorptives and for whom orthopantomography was available, analyzed and compared with 20 healthy children. The panoramic radiographs were analyzed and the radiomorphometric indices and fractal dimension were measured after first selecting the areas of interest to be studied. The results showed that fractal dimension of the basal cortical bone was lower in the study group, and MCW was lower in patients with osteogenesis imperfecta. In addition, MCW and fractal dimension were lower with higher number of treatment cycles received. In light of the results obtained, we can conclude that panoramic radiography can be useful in analyzing changes in bone mineral density in these patients throughout the course of treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Orthopantomography in the Analysis of Bone Mineral Density in Patients with Osteogenesis Imperfecta

García-Boedo,

Burgueño-Torres,

de Nova-García

2024

Applied Sciences

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“…In many studies in the literature in recent years, it has been shown that changes in bone structure can be examined with FD in conditions affecting bone structure such as osteoporosis, hyperparathyroidism, osteoarthritis or osteogenesis imperfecta [ 9 , 16 , 32 , 33 ]. In these studies, the differences in bone structure between healthy and sick individuals, as well as the effectiveness of treatments applied to sick individuals in some of the studies, were examined by comparing the changes in FD values occurring in the bone structure.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of trabecular changes following advancement genioplasty combined with or without bilateral sagittal split osteotomy by fractal analysis: a retrospective cohort study

et al. 2023

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Background It is aimed to investigate whether there was a difference in radiographic changes in the operational areas between genioplasty alone and genioplasty combined with mandibular advancement and to evaluate the fractal dimension (FD) to assess trabecular changes after genioplasty surgery. Methods Preoperative-(T0) and postoperative-(T1) panoramic radiographs of 26 patients without any complications who underwent genioplasty combined with bilateral sagittal osteotomy and mandibular advancement or genioplasty alone were selected. In the panoramic radiographs of both groups, the genial segment, mandibular angulus, and surgical osteotomy line were examined using FD. The box-counting method was used for FD evaluation. Results It was determined that FD values before and after treatment were similar in both groups for all regions where measurements were made. After surgery, the FD values of the middle region of the genial segment were found to be significantly lower than the other regions. At T1, the FD values at the osteotomy area were found to be significantly higher than those in the middle region of the genial segment. Conclusion Trabecular structure does not differ in patients undergoing genioplasty alone or in combination with mandibular advancement osteotomy. The middle region of the genial segment heals later than other regions.

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Craniofacial and dental phenotype of two girls with osteogenesis imperfecta due to mutations in CRTAP

Marulanda

Ludwig

Glorieux

et al. 2022

Bone

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Pamidronate Therapy Increases Trabecular Bone Complexity of Mandibular Condyles in Individuals with Osteogenesis Imperfecta

Cited by 6 publications

References 45 publications

Application of Orthopantomography in the Analysis of Bone Mineral Density in Patients with Osteogenesis Imperfecta

Application of Orthopantomography in the Analysis of Bone Mineral Density in Patients with Osteogenesis Imperfecta

Evaluation of trabecular changes following advancement genioplasty combined with or without bilateral sagittal split osteotomy by fractal analysis: a retrospective cohort study

Craniofacial and dental phenotype of two girls with osteogenesis imperfecta due to mutations in CRTAP

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