Pan-cortical coordination underlying mental effort

Lesser, Ronald P.; Webber, W. R.; Miglioretti, Diana L.

doi:10.1016/j.clinph.2021.12.021

Cited by 2 publications

(6 citation statements)

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“…We calculated WxCoh for all electrode contact pairs over a range of wavelet scales with peak frequencies from 7.13 to 40.05 Hz. These in our previous papers had been significantly associated with AD termination [5][6][7] , and spectral analysis had shown these to contain the majority of the WxCoh changes 7 . For these calculations, a scale can be thought of as a surrogate for frequency.…”

Section: Analysis Of Electrocorticographymentioning

confidence: 82%

“…We compared these segments to a baseline which we called B4 and which occurred before the beginning of the question. To obtain this baseline, we began with the 4-s baseline described in previous papers 4,5 . We divided the 4 s into four consecutive one-second segments and averaged these, with a resulting 1-s baseline.…”

Section: Clinical Testingmentioning

confidence: 99%

“…We also separated the recordings for each of these segments into five additional subgroups 5 . The first subgroup, 10% of the total, consisted of electrode contacts whose centers were 1.9 cm or less from one another, i.e., the eight nearest neighbors.…”

Section: Clinical Testingmentioning

confidence: 99%

“…To understand this further, we next separated the inter-contact combinations by inter-contact distance 5 . Coherence decreases continued to be found, regardless of the distance between electrode contacts in a pair.…”

Section: Cognitive Tasks and Afterdischarge Terminationmentioning

confidence: 99%

“…Based on these results, we now divided the inter-contact coherence groups into 25 groups, combining the five distance groups 5 and the five time segment groups 7 . Overall, there were no significant differences between Table 3.…”

Section: Cognitive Tasks and Afterdischarge Terminationmentioning

confidence: 99%

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Pan-cortical electrophysiologic changes underlying attention

Lesser,

Webber,

Miglioretti

2024

Sci Rep

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We previously reported that pan-cortical effects occur when cognitive tasks end afterdischarges. For this report, we analyzed wavelet cross-coherence changes during cognitive tasks used to terminate afterdischarges studying multiple time segments and multiple groups of inter-electrode-con distances. We studied 12 patients with intractable epilepsy, with 970 implanted electrode contacts, and 39,871 electrode contact combinations. When cognitive tasks ended afterdischarges, coherence varied similarly across the cortex throughout the tasks, but there were gradations with time, distance, and frequency: (1) They tended to progressively decrease relative to baseline with time and then to increase toward baseline when afterdischarges ended. (2) During most time segments, decreases from baseline were largest for the closest inter-contact distances, moderate for intermediate inter-contact distances, and smallest for the greatest inter-contact distances. With respect to our patients’ intractable epilepsy, the changes found suggest that future therapies might treat regions beyond those closest to regions of seizure onset and treat later in a seizure’s evolution. Similar considerations might apply to other disorders. Our findings also suggest that cognitive tasks can result in pan-cortical coherence changes that participate in underlying attention, perhaps complementing the better-known regional mechanisms.

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