PanaxGDB: A Comprehensive Platform for Panax

Abstract

The genus Panax is a valuable natural medicinal source used worldwide that contains high levels of triterpenoid saponins with extensive pharmacological activities. In past decades, molecular biotechnology and breeding techniques have been respectively used to generate omics data and information on cultivars primarily from Panax ginseng (ginseng), Panax quinquefolium (American ginseng), and Panax notoginseng (Sanqi) to biosynthesize valuable saponins, improve product quality, and conduct cost-controlled cultivation. Although much data have been produced, there are concerns that redundant data might be generated and that relatively scattered data might be overlooked. Therefore, many scientists desire a reliable, comprehensive omics database of the Panax genus that could save time and promote integrated analysis. Therefore, to provide all-inclusive, reliable, and valuable information on the Panax genus, PanaxGDB, an open comprehensive database that integrates data on omics and information on varieties, was established. The database contains information on nearly 600 compounds from 12 Panax species, draft genomic sequences with annotations and gene expression levels, single nucleotide polymorphisms, genome-wide association analysis based on agronomic traits, globally collected germplasm information, summaries, omics data of the Panax genus, and online versatile analytic tools. The Panax genus database will be updated when new data are released to continue serving as a central portal to boost research on the biology and functions of Panax. PanaxGDB is available at: http://panaxGDB.ynau.edu.cn.

Reconstruction of engineered yeast factory for high yield production of ginsenosides Rg3 and Rd

“…A total of 116 UGT s from P. notoginseng were obtained from the PanaxGDB database 1 ( Lin et al, 2022 ). According to previous studies, UGTs that catalyze dammarane-type ginsenoside belong mainly to the UGT 74, 94, and 71 families.…”

Perspective and challenges of mycorrhizal symbiosis in orchid medicinal plants

“…fungi provide nutrients for the growth and development of G. elata tuber and obtain nutrients from it ( Xu, 2013 ). The bilateral flow of nutrients is the material basis of symbiotic partnerships between G. elata and fungi ( Liu et al, 2024 ). Xu et al isolated M. osmundicola from the protocorms of G. elata and confirmed that the fungi can effectively increase G. elata seed germination to up to 70% ( Xu et al, 1980 , Xu & Guo, 1989 ).…”

β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng

“…In the Panax genus, 13 Panax species were identified (accessed on 17 April 2023 from http://www.theplantlist.org). Some Panax species have a long history of use in traditional medicine due to their composition and functionality [1]. Korean ginseng (Panax ginseng) is considered one of the most precious medicinal plants, owing to the abundance of ginsenosides of highly economical and medicinal value; however, this form of ginseng also contains additional potentially useful secondary compounds, including polysaccharides, proteins, peptides, amino acids, polyphenols, polyacetylenes, alkaloids, lipids, essential oils, phytosterols, organic acids, and terpenes [2][3][4][5][6][7].…”

“…Many such compounds, including caffeic acid, vanillic acid, coumaric acid, ferulic acid, gentisic acid, cinnamic acid, and polyactetylenes, have been reported to possess biological and pharmacological activity as antioxidants, anti-inflammatory, and/or anticancer agents [ 2 , 4 , 8 , 9 , 10 ]. P. ginseng has been utilized to investigate various pharmaceutical applications, including use as antioxidants, anticancer, anti-inflammatory, anti-hyperglycemic, treating cardiovascular and cerebrovascular diseases, and boosting the immune system [ 1 , 2 , 4 , 5 ].…”