Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα

Zhang, Lingming; Yan, Jingdi; Liu, Jianming; Meng, Chao; Liu, Fanglan; Xia, Chunhua

doi:10.1016/j.phymed.2022.154097

Cited by 12 publications

(2 citation statements)

References 34 publications

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“…The interaction centered by PXR will illustrated the multifunctional property of it in different signaling pathways (41). Being part of a chaperone protein complex consisting of heat shock protein 90 (Hsp90) and CAR cytoplasmic retention protein (CCRP), PXR is predominantly localized in the cytoplasm (42). After activation by ligand binding, PXR is transferred from the cytoplasm to the nucleus and forms a heterodimer with retinoid X receptor (RXR).…”

Section: The Transcriptional Regulatory Characteristics Of Pxrmentioning

confidence: 99%

The role of pregnane X receptor (PXR) in substance metabolism

Luo

Ren

et al. 2022

Front. Endocrinol.

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As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals. The tissue distribution of PXR is parallel to its function with high expression in the liver and small intestine and moderate expression in the kidney, stomach, skin, and blood-brain barrier, which are organs and tissues in frequent contact with xenobiotics. PXR was first recognized as an exogenous substance receptor regulating metabolizing enzymes and transporters and functioning in detoxification and drug metabolism in the liver. However, further research revealed that PXR acts as an equally important endogenous substance receptor in the metabolism and homeostasis of endogenous substances. In this review, we summarized the functions of PXR in metabolism of different substances such as glucose, lipid, bile acid, vitamin, minerals, and endocrines, and also included insights of the application of PXR ligands (drugs) in specific diseases.

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Section: The Transcriptional Regulatory Characteristics Of Pxrmentioning

confidence: 99%

The role of pregnane X receptor (PXR) in substance metabolism

Luo

Ren

et al. 2022

Front. Endocrinol.

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“…At high concentrations, CAR was involved in the regulation of CYP3A4 through a similar mechanism. Moreover, during the upregulation of PXR-CYP3A4 by PNT triol, CAR can interactively inhibit PXR by counteracting its binding to RXRα ( Zhang, 2021 ).…”

Section: Anti-tumor Mechanism Of Action Of the Active Ingredients Of ...mentioning

confidence: 99%

Research progress of ginseng in the treatment of gastrointestinal cancers

Song²,

Shi³

et al. 2022

Front. Pharmacol.

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Cancer has become one of the major causes of human death. Several anticancer drugs are available; howeve their use and efficacy are limited by the toxic side effects and drug resistance caused by their continuous application. Many natural products have antitumor effects with low toxicity and fewer adverse effects. Moreover, they play an important role in enhancing the cytotoxicity of chemotherapeutic agents, reducing toxic side effects, and reversing chemoresistance. Consequently, natural drugs are being applied as potential therapeutic options in the field of antitumor treatment. As natural medicinal plants, some components of ginseng have been shown to have excellent efficacy and a good safety profile for cancer treatment. The pharmacological activities and possible mechanisms of action of ginseng have been identified. Its broad range of pharmacological activities includes antitumor, antibacterial, anti-inflammatory, antioxidant, anti-stress, anti-fibrotic, central nervous system modulating, cardioprotective, and immune-enhancing effects. Numerous studies have also shown that throuth multiple pathways, ginseng and its active ingredients exert antitumor effects on gastrointestinal (GI) tract tumors, such as esophageal, gastric, colorectal, liver, and pancreatic cancers. Herein, we introduced the main components of ginseng, including ginsenosides, polysaccharides, and sterols, etc., and reviewed the mechanism of action and research progress of ginseng in the treatment of various GI tumors. Futhermore, the pathways of action of the main components of ginseng are discussed in depth to promote the clinical development and application of ginseng in the field of anti-GI tumors.

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Metabolic disrupting chemicals in the intestine: the need for biologically relevant models

Erradhouani,

Bortoli,

Aït‐Aïssa

et al. 2024

FEBS Open Bio

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Although the concept of endocrine disruptors first appeared almost 30 years ago, the relatively recent involvement of these substances in the etiology of metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to the concept of Metabolic Disrupting Chemicals (MDCs). Organs such as the liver and adipose tissue have been well studied in the context of metabolic disruption by these substances. The intestine, however, has been relatively unexplored despite its close link with these organs. In vivo models are useful for the study of the effects of MDCs in the intestine and, in addition, allow investigations into interactions with the rest of the organism. In the latter respect, the zebrafish is an animal model which is used increasingly for the characterization of endocrine disruptors and its use as a model for assessing effects on the intestine will, no doubt, expand. This review aims to highlight the importance of the intestine in metabolism and present the zebrafish as a relevant alternative model for investigating the effect of pollutants in the intestine by focusing, in particular, on cytochrome P450 3A (CYP3A), one of the major molecular players in endogenous and MDCs metabolism in the gut.

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Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα

Cited by 12 publications

References 34 publications

The role of pregnane X receptor (PXR) in substance metabolism

The role of pregnane X receptor (PXR) in substance metabolism

Research progress of ginseng in the treatment of gastrointestinal cancers

Metabolic disrupting chemicals in the intestine: the need for biologically relevant models

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