Pancreas transplantation: An update

Islet cell transplantation today

“…In 1992, Pyzdrowski et al at the University of Minnesota in Minneapolis, USA reported a series of five patients who became insulin independent after intrahepatic islet autotransplantation after total or near-total pancreatectomy for severe chronic pancreatitis [35]. From this study and other reports we learned that a critical mass of 300,000 islets implanted in the liver could reestablish and maintain insulin independence in the setting of an autotransplantation [36,37]. Of the 275 well-documented islet cell autografts recorded in the International Islet Transplant Registry (ITR) in Giessen, Germany database from 1990 to 2005, 48 and 75% of recipients were insulin-independent at 1 year after transplantation if less than or more than 300,000 islet equivalents (IEQ) per recipient were grafted, respectively (Table 3) [9].…”

The Testicular-Derived Sertoli Cell: Cellular Immunoscience to Enable Transplantation

“…The logic of replacing several decades we have gained an increasingly sophistilost populations of cells is inherently appealing: animal cated knowledge of the biological and molecular mechastudies and recent clinical studies have clearly demonnisms of numerous degenerative diseases. At the same strated that transplanted cells can survive and promote time, advances in combinatorial chemistry, genetic enfunctional recovery (29,54,58,92,103,110,113,114). Degineering, genomics, and proteomics are increasing the spite this promise, the limited tissue availability and the number of proteins, peptides, and other compounds with need for chronic systemic immunosuppression are major treatment potential.…”

“…Attempts at experibelow for a detailed discussion of this and other mechanistic possibilities), strongly implying a natural role in mental pancreas or islet transplantation date back to before the discovery of insulin and, up until several years contributing to the maintenance of the local immune privilege of the testes. The following sections describe ago, have been met with limited success (55,113,114). Recently, Shapiro and colleagues (92,103) in Edmonton recent efforts to harness the immunomodulatory capacity of Sertoli cells to facilitate cell grafting in diabetes reported insulin independence in patients receiving islet cell allografts with immunosuppression, providing the and PD.…”

Duodenal Histology for Monitoring Treatment of Acute Rejection in Pancreaticoduodenal Allografts in Rats1,2

“…Pancreas and kidney transplantation has emerged as the treatment of choice in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy (1). The outcome of pancreas transplantation has significantly improved during the last decade as new immunosuppressive drugs were introduced into clinical practice and the surgical technique has been refined.…”