Pancreatic hamartoma mimicking neuroendocrine tumor

Ahn, Ae Ri; Song, Ji Soo; Yang, Jae Do; Moon, Woo Sung

doi:10.1111/pin.13153

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…Our case shows that pancreatic hamartoma can be preoperatively diagnosed using EUS–FNAB. Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 .…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 . Furthermore, preoperative diagnosis using various techniques, such as CT, MRI, or US, is extremely difficult because various neoplasms, such as NET, solid pseudopapillary neoplasm, and adenocarcinoma, are included in the differential diagnosis, as described in the case report and literature review by Noguchi et al 1 In our case, the imaging findings suggested NET, although some features were atypical.…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound–guided fine‐needle aspiration biopsy

Shintaku

Gokita

Oshima

et al. 2023

Diagnostic Cytopathology

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Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is useful for preoperatively diagnosing various pancreatic tumors. Although there is a risk of complications, such as pancreatitis, this procedure achieves the crucial need of reducing unnecessary invasive surgery for benign lesions. Herein, we reported a surgically resected case of pancreatic hamartoma in the pancreatic head whose retrospective analysis revealed that the specimens obtained via EUS-FNAB contained hamartoma fragments. Pancreatic hamartoma is an extremely rare benign disease that is exceptionally difficult to diagnose before surgical resection owing to its rarity and lack of established imaging findings. To the best of our knowledge, the preoperative diagnosis of pancreatic hamartoma via EUS-FNAB specimens has not been reported to date. Herein, postoperative EUS-FNAB evaluation revealed a collection of pancreatic hamartoma lesions, although the initial diagnosis was pancreatic tissue with focal atrophy and fibrosis. Diagnosis using EUS-FNAB can be challenging owing to the very small sample size. If mature acini and ducts with fibrous stroma without islets are observed in the EUS-FNAB specimen, pancreatic hamartoma should be considered as a differential diagnosis. Thus, careful follow-up or reexamination of EUS-FNAB should be considered instead of surgery if a benign lesion is suspected preoperatively.

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Section: Discussionmentioning

confidence: 99%