Pancytopenia in Zimbabwe

Savage, David G.; Allen, Robert H.; Gangaidzo, Innocent T.; Lévy, L.; Gwanzura, Christine; Moyo, Alpha; Mudenge, Boniface; Kiire, C.F.; Mukiibi, Joshua; Stabler, Sally P.; Lindenbaum, John

doi:10.1097/00000441-199901000-00004

Cited by 46 publications

(36 citation statements)

References 15 publications

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“…The incidence of Megaloblastic anemia between the two groups is statistically significant with P<0.01. Similar observation has also been reported by David et al and Tilak et al 3,11 Thus, in contrast to the age group more than 14 years Megaloblastic anemia is a rare cause of pancytopenia in the pediatric age group.…”

Section: Discussionsupporting

confidence: 88%

Pancytopenia: etiologies and manifestation in eastern India

Singh

2017

Int J Res Med Sci

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Background: Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aetiologies causing pancytopenia varies depending upon factors e.g. age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of haematology give more emphasis to Aplastic anaemia; while Megaloblastic anaemia is more common in developing countries than western world. Therefore, this Observational study was carried out over a period of two years in the Department of Medicine of Institute of Medical Sciences (IMS), BHU with the aim to identify etiologies of pancytopenia and its manifestation in eastern India.Methods: All the patients with features of anemia, thrombocytopenia or leukopenia were screened for pancytopenia and a total 214 cases were selected. A detailed physical examination, hematological and biochemical investigation was done.Results: The most common cause of pancytopenia in our study was Aplastic anemic (36.9%) followed by Megaloblastic anaemia (18.7%), Kala-azar (11.7%) and Myelodysplastic syndrome (10.5%).Conclusions: Megaloblastic anemia should be considered as important cause of Pancytopenia, especially when serum LDH level of patient is raised.

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Section: Discussionsupporting

confidence: 88%

Pancytopenia: etiologies and manifestation in eastern India

Singh

2017

Int J Res Med Sci

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“…Bhaskar Thakkar et al [17] found megaloblastic anaemia (37%) to be the primary predominant aetiological factor for pancytopenia while malaria (19%) interestingly was found as second commonest cause. Savage et al [18] from Zimbabwe found megaloblastic anaemia (35.8%) to be the predominant clinical entity responsible for pancytopenia while Pine at al [19] in their study conducted in the United States of America found entirely different causative factor for pancytopenia in the form of infectious diseases in a whopping 64% of pancytopenia patients which compares favourably with the most common cause of pancytopenia found in the present study.…”

Section: Discussionsupporting

confidence: 67%

Hematologic Analysis of Pancytopenia and Correlation with Bone Marrow Findings: Study in a Tertiary Care Centre

Mahore¹

2017

JMSCR

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“…9 The different causes of Pancytopenia may be attributed to multitude of factors such as geographical and genetic variations, nutrition, prevalence of certain In this study a total number of 244 cases of Pancytopenia were studied. Age, sex distribution, presenting complaints and various causes of Pancytopenia were studied in all these cases, and observations were compared with studies already published in Pakistan as well as other neighboring parts of the world.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Pancytopenia; A Tertiary Care Experience

Rehmani¹,

Arif²,

Haider³

et al. 2016

TPMJ

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ORIGINAL PROF-3398ABSTRACT… Pancytopenia refers to a reduction in all the three cellular elements of blood. Pancytopenia is a common but important hematological problem encountered in routine clinical Practice. It may be a presenting feature of many underlying serious and life threatening illnesses. Objective: Present study was planned to appraise various clinico-etiological factors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: Hematology Department of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period: July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients with Pancytopenia were included in the study. Complete blood count, bone marrow aspirations and trephine biopsies were performed after clinical history and physical exam. Data were analyzed by using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bone marrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiological factors with male predominance. Fever and pallor were striking presenting clinical features. Conclusion:We conclude that Pancytopenia is a common problem with an exhaustive list of differential diagnosis, some of which are easily treatable and reversible. Therefore early detection with optimal diagnostic approach to Pancytopenia is required for better management of patients. Key words:Pancytopenia, Aplastic anemia, Megaloblastic anemia, Bone marrow.

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Pancytopenia in Zimbabwe

Cited by 46 publications

References 15 publications

Pancytopenia: etiologies and manifestation in eastern India

Pancytopenia: etiologies and manifestation in eastern India

Hematologic Analysis of Pancytopenia and Correlation with Bone Marrow Findings: Study in a Tertiary Care Centre

Spectrum of Pancytopenia; A Tertiary Care Experience

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