Panniculitis as the initial manifestation of dermatomyositis with anti-MDA5 antibody

Hasegawa, Akito; Shimomura, Yutaka; Kibune, Natsuko; Koshio, Jun; Umemori, Yukie; R, Abe

doi:10.1111/ced.13128

Cited by 14 publications

(13 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histopathologic examination revealed lobular panniculitis with lymphoplasmacytic infiltrate . Since then, we have found descriptions of 39 cases in the English literature …”

Section: Discussionmentioning

confidence: 97%

“…One of our patients showed erythematous nodules involving the face, and there is only one report of DM panniculitis causing ‘lipoatrophy’ on the face, but no biopsy was performed from these lesions. DM panniculitis seems to be associated with non‐aggressive forms of DM, because although all described patients had muscular weakness and inflammatory myopathy in the biopsy, only one patient developed panniculitis as the initial manifestation of DM with anti‐MDA5 antibody and rapid progressive interstitial pneumonia and only three cases of DM panniculitis were associated with neoplasms, including ovarian adenocarcinoma, parotid carcinoma and rhabdomyosarcoma . No neoplasm was detected in our patients neither before the diagnosis of DM nor during the follow‐up.…”

Section: Discussionmentioning

confidence: 99%

“…Panniculitis is less frequent in DM than in systemic lupus erythematosus and systemic sclerosis, and a review of the literature reveals that most published cases are single case reports . In a series of 55 adult patients with DM and cutaneous lesions studied histopathologically, panniculitis was only found in five cases .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases

Santos‐Briz

Calle

Linos

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Histopathologic examination revealed lobular panniculitis with lymphoplasmacytic infiltrate . Since then, we have found descriptions of 39 cases in the English literature …”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases

Santos‐Briz

Calle

Linos

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…DM/CADM should be considered, particularly when intractable panniculitis is noted. Panniculitis and myositis have shown simultaneous improvement during treatments [ 14 , 15 ] and a parallel flare and remission. In the present case, although panniculitis disappeared by steroid and tacrolimus treatment and did not recur, muscle weakness recurred with an increase in CK and myoglobin levels.…”

Section: Discussionmentioning

confidence: 99%

Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom

et al. 2018

View full text Add to dashboard Cite

Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. The patient developed typical skin eruptions of DM/CADM, rapidly progressive interstitial lung disease, and severe muscle weakness 2 weeks after the first visit. After the diagnosis of anti-MDA5 antibody-positive DM, she was treated with intravenous steroid pulse therapy (methylprednisolone, 1,000 mg/day for 3 days), oral prednisolone at 1.0 mg/kg/day, and tacrolimus at 4.0 mg/day. The lesions of panniculitis associated with DM/CADM typically present on the buttocks, thighs, arms, and abdomen. This is the first DM/CADM case with localized panniculitis on the face. Panniculitis and myositis usually show simultaneous improvement during treatment. Although panniculitis disappeared with steroid and tacrolimus treatment and did not recur, muscle weakness was intractable and recurred in this case. This indicates that the clinical courses of panniculitis and myositis of DM/CADM do not always change in parallel.

show abstract

“…тах -в 1% [8], при системной склеродермии (ССД) -в 8% [7,9], при дерматомиозите (ДМ) -в 10% [7,10], при болез-ни Бехчета -в 25-50% [6].…”

unclassified

Panniculitis: rheumatological aspects

Егорова¹,

Белов²

2018

RJTAO

View full text Add to dashboard Cite

Panniculitis as the initial manifestation of dermatomyositis with anti-MDA5 antibody

Cited by 14 publications

References 6 publications

Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases

Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases

Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom

Panniculitis: rheumatological aspects

Contact Info

Product

Resources

About