Papel de los antioxidantes en la prevención de la enfermedad cardiovascular

Páramo, Ángel José Lorente; Orbe, Mera; Rodríguez, José Antonio

doi:10.1016/s0025-7753(01)71926-4

Cited by 7 publications

(1 citation statement)

References 78 publications

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“…Todos estos parámetros se pueden influir por tratamientos bloqueantes del sistema de la angiotensina y con estatinas. También disminuye el riesgo de presentar clínica cardiovascular con el uso de fármacos antioxidantes, lo cual apunta indirectamente a la importancia del estrés oxidativo en el proceso de la lesión vascular 58,59 .…”

Section: Conclusionesunclassified

[The inflammatory process of cardiovascular disease: new markers

2009

An Sist Sanit Navar

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RESUMENEl modelo clásico a través del que se ha explicado durante décadas la génesis de la ateromatosis es aquel que implica a los factores clásicos de riesgo cardiovascular, y éstos causados bien por estilos de vida perjudiciales, bien por alteraciones hereditarias del metabolismo, principalmente las dislipemias.Recientemente estamos aprendiendo que, si bien lo anterior es cierto, no lo es menos que íntimos procesos moleculares, entre los que se cuentan las cascadas de citoquinas y celulares de la inflamación, explican gran parte del daño vascular que conduce a los episodios isquémicos que se observan en la clínica. Incluso puede afirmarse en general que los marcadores séricos de la inflamación, como hipotéticas herramientas de diagnóstico precoz de la enfermedad vascular, se encuentran en la senda fisiopatológica entre el factor de riesgo clásico (hipertensión arterial, hipercolesterolemia, obesidad, diabetes) y la lesión arterial.En este artículo se describen estos mecanismos inflamatorios, tanto bajo el punto de vista de la ciencia básica como en su papel clínico, sin olvidar el valor epidemiológico que podrían tener en el estudio de poblaciones. ABSTRACTFor many years the classic model used for explaining the genesis of atheromatosis was that involving classic cardiovascular risk factors, caused either by a harmful life style or by hereditary alterations of the metabolism, principally dislipaemias.Recently we have learnt that, intimate molecular processes, as the inflammatory cytokine and cellular cascades, explain a great part of the vascular damage leading to the ischaemic episodes observed in the clinic. It can even be assessed, in general, the seric inflammation markers, as hypothetical tools for early diagnosis of vascular disease, are located on the physiopathological path between the classic risk factor (arterial hypertension, hypercholesterolaemia, obesity, diabetes) and the arterial lesion.This paper describes these inflammatory mechanisms, both from the viewpoint of basic science and from the viewpoint of its clinical role, and it also analyses the epidemiological value that these might have in the study of populations.

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Section: Conclusionesunclassified

[The inflammatory process of cardiovascular disease: new markers

2009

An Sist Sanit Navar

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Alterations in the choroid in hypercholesterolemic rabbits: Reversibility after normalization of cholesterol levels

Salazar

Ramírez

Hoz

et al. 2007

Experimental Eye Research

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Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis

2003

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As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion. A number of imaging modalities (vascular ultrasound, MRI, and coronary computed tomography) are used for non-invasive assessment of atherosclerosis; most of them can identify luminal stenosis, wall thickness and plaque volume and composition, and can even characterize the rupture-prone vulnerable plaques. Several classes of drugs, including statins, ACE inhibitors, -blockers, and antithrombotics, are able to reduce the plaque burden and the incidence of cardiovascular events; this may be attibutable, at least in part, to plaque-stabilizing effects and the improvement of endothelial dysfunction.

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Papel de los antioxidantes en la prevención de la enfermedad cardiovascular

Cited by 7 publications

References 78 publications

[The inflammatory process of cardiovascular disease: new markers

[The inflammatory process of cardiovascular disease: new markers

Alterations in the choroid in hypercholesterolemic rabbits: Reversibility after normalization of cholesterol levels

Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis

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