Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas

Contreras-Duarte, Susana; Varas, Pablo; Awad, Fernanda; Busso, Dolores; Rigotti, Attilio

doi:10.4067/s0716-10182014000100005

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…Once ruminal free LPS enters the blood stream through the portal vein, the LPS can initiate potent pro-inflammatory response, leading to laminitis and sudden death syndrome 13 . Previous studies increasingly indicated the role of HDL and other lipoproteins in controlling the host response to free LPS 76 , through the binding of HDL to LPS 77 . This binding inhibited the ability of LPS to interact with toll-like receptors and activate macrophages, and thus reduced the chances of septic shock and related death 78 .…”

Section: Discussionmentioning

confidence: 99%

Changes in meta-transcriptome of rumen epimural microbial community and liver transcriptome in young calves with feed induced acidosis

Gelsinger

Edwards

et al. 2019

Sci Rep

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The common management practices of dairy calves leads to increased starch concentration in feed, which subsequently may cause rumen acidosis while on milk and during weaning. Until recently, few attempts were undertaken to understand the health risks of prolonged ruminal acidosis in post weaning calves. Resultantly, the molecular changes in the digestive tracts in post-weaning calves with ruminal acidosis remain largely unexplored. In this study, we investigated the liver transcriptome changes along with its correlation with the rumen microbial rRNA expression changes in young calves using our model of feed induced ruminal acidosis. In this model, new born calves were fed a highly processed, starch-rich diet starting from one week of age through 16 weeks. A total of eight calves were involved in this study. Four of them were fed the acidosis-inducing diet (Treated) and the rest of the four were fed a standard starter diet (Control). Liver and rumen epithelial tissues were collected at necropsy at 17 weeks of age. Transcriptome analyses were carried out in the liver tissues and rRNA meta-transcriptome analysis were done using the rumen epithelial tissues. The correlation analysis was performed by comparing the liver mRNA expression with the rumen epithelial rRNA abundance at genus level. Calves with induced ruminal acidosis had significantly lower ruminal pH in comparison to the control group, in addition to significantly less weight-gain over the course of the experiment. In liver tissues, a total of 428 differentially expressed genes (DEGs) (fold-change, FC ≥ 1.5; adjusted P ≤ 0.1) were identified in treated group in comparison to control. Biological pathways enriched by these DEGs included cellular component organization, indicating the impact of ruminal acidosis on liver development in young calves. Specifically, the up-regulated genes were enriched in acute phase response (P < 0.01), pyruvate metabolic process (P < 0.01) and proton-acceptors (P ≪ 0.001), indicating the liver’s response to feed induced acidosis at the transcriptome level. Twelve transferase activity related genes had significant correlation with rumen microbial rRNA expression changes. Among these genes, two up-regulated genes were reported with involvement in lipid metabolism in the liver, implying the direct effect of feed-induced acidosis on both the rumen microbial community and liver metabolism. Our study provides insight into the physiological remodeling in the liver resultant from the prolonged acidosis in post weaning calves, which may facilitate future RNA-seq based diagnosis and precision management of rumen acidosis in dairy calves.

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Section: Discussionmentioning

confidence: 99%

Changes in meta-transcriptome of rumen epimural microbial community and liver transcriptome in young calves with feed induced acidosis

Gelsinger

Edwards

et al. 2019

Sci Rep

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“…This is partly attributable to the fact that lipoprotein can neutralize LPS in the body. There was evidence that lipoproteins can neutralize LPS in vivo [28] . Several experiments have also demonstrated that plasma lipoprotein, especially HDL, can be combined with LPS and preferentially shunt liver cells away from liver macrophages, thereby increasing LPS excretion through the bile and preventing immune responses [29] .…”

Section: Discussionmentioning

confidence: 99%

Büyüme Dönemindeki Keçilerde Pirinç Ağırlıklı Diyetin Büyüme Performansı, Görünür Sindirilebilirlik, Nitrojen Metabolizması, Kan Parametreleri ve Rumen Fermentasyonu Üzerine Etkileri

Wang¹,

Zheng²,

Ren³

et al. 2019

Kafkas Univ Vet Fak Derg

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This study was conducted to evaluate the effects of high rice grain diet on apparent nutrient digestibility, growth performance, nitrogen digestion, blood parameters and rumen fermentation in goats. Sixteen growing goats were divided into 2 groups and fed a normalconcentrate diet (NC, 55% concentrate of dry matter; n=8) or a high concentrate diet (HC, 90% concentrate of dry matter; n=8) for 5 wk. Growth performance, nutrients digestibility, nitrogen digestion, blood parameters and ruminal fermentation were measured. Total weight gain and average daily gain increased in the HC group (P<0.01). Digestibility of Neutral Detergent Fibre (NDF) and Acid Detergent Fibre (ADF), nitrogen intake and digested nitrogen also increased (P<0.05) by HC feeding. Triglycerides, cholesterol, high density lipoprotein and low-density lipoprotein concentrations in the blood decreased (P<0.05). HC diet feeding decreased (P<0.01) the pH value, acetate level and ratio of acetate to propionate, but increased (P<0.05) the concentrations of propionate, valerate and total volatile fatty acids in the rumen. These findings revealed that the HC diet could promote the growth of growing goats, change the ruminal fermentation pattern and lipid metabolism in the blood, but cause subacute ruminal acidosis, which might increase the risk of body health.

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“…Likewise, it has been observed that it has action in the innate immunity since it is able to sequester the lipopolysaccharides (LPS) of bacterial origin and eliminate it by the hepatobiliary route, this way limiting the inflammatory cascade that participates in sepsis and shock. In a population study, the role of HDL cholesterol as a prognostic marker in sepsis is being studied [87].…”

Section: Insulin and The Control Of Lipids In The Context Of The Septmentioning

confidence: 99%

Insulin, More than a Metabolic Hormone; Focuse in Sepsis Beyond Glucose Control

2018

IJDMD

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Sepsis is the result of an inadequate and harmful host response caused by an infection. Within this, multiple pathways are activated to resolve the infection, however the inappropriate activation of these comes to compromise different systems that explain the complexity of sepsis. Insulin has been studied extensively in terms of the control of hyperglycemia in sepsis, but the benefits of insulin can not only be attributed to glucose control per se, in this review we present some of the other functions that insulin fulfills in the sepsis beyond the control of glycemia. Materials and Methods: We reviewed Pubmed, Ovid, Embase, Lilacs and published textbook chapters, all articles related to physiopathology and effects of insulin in sepsis. Articles carried out in humans and animals were included, without limit of publication date. Conclusion: Insulin has different functions in sepsis beyond the control of glucose, in which the control or regulation of the inflammatory response is the fundamental axis, since it is involved in all the mechanisms that relate sepsis to insulin. It can not be determined what percentage or proportion of the insulin benefit is due to the control of glucose or the regulatory mechanism on inflammation, microcirculation, expression of free radicals, etc. The understanding of insulin in the different pathophysiological pathways of sepsis should be further deepened since the decomposition of the functions of this hormone as well as of other alternate routes, is what will allow the optimization of all the therapeutic arsenals that exist to improve the morbidity and mortality of these patients.

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Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas

Cited by 12 publications

References 27 publications

Changes in meta-transcriptome of rumen epimural microbial community and liver transcriptome in young calves with feed induced acidosis

Changes in meta-transcriptome of rumen epimural microbial community and liver transcriptome in young calves with feed induced acidosis

Büyüme Dönemindeki Keçilerde Pirinç Ağırlıklı Diyetin Büyüme Performansı, Görünür Sindirilebilirlik, Nitrojen Metabolizması, Kan Parametreleri ve Rumen Fermentasyonu Üzerine Etkileri

Insulin, More than a Metabolic Hormone; Focuse in Sepsis Beyond Glucose Control

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