Paper-based chemiluminescence immunodevice with temporal controls of reagent transport technique

Chu, Weiru; Chen, Ying; Liu, Wei; Zhao, Mei; Li, Huifang

doi:10.1016/j.snb.2017.04.126

Cited by 46 publications

(30 citation statements)

References 51 publications

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“…The fluid control method with surfactants and dissolving materials, such as sucrose, has the advantage of being simple in structure, but using materials, such as ethanol, as mentioned in previous studies, may affect samples or downstream reactions. However, if verified materials, such as tween, which is often utilized in immunoassay using various antibodies, or sucrose, which is widely applied to dry and preserve antibody conjugates used in multi-step reactions, such as ELISA, are used, accurate assays can be performed without any significant impact on downstream action [49,61]. In addition, optimizing the deposition concentration of the surfactant or sugar has little effect on valve opening, on the solubility of each reagent, or on delivery capability, thus showing In addition to fluid velocity control technology, switching methods using the principle of linking disconnected parts or blocking channels are also widely used in passive fluid manipulation technology.…”

Section: Dissolvable Materials (Sucrose) Fluid Velocity Controlmentioning

confidence: 99%

Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

Kim¹,

Hahn

Kim

2020

Micromachines

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Microfluidic paper-based analytical devices (μPADs) have been suggested as alternatives for developing countries with suboptimal medical conditions because of their low diagnostic cost, high portability, and disposable characteristics. Recently, paper-based diagnostic devices enabling multi-step assays have been drawing attention, as they allow complicated tests, such as enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), which were previously only conducted in the laboratory, to be performed on-site. In addition, user convenience and price of paper-based diagnostic devices are other competitive points over other point-of-care testing (POCT) devices, which are more critical in developing countries. Fluid manipulation technologies in paper play a key role in realizing multi-step assays via μPADs, and the expansion of biochemical applications will provide developing countries with more medical benefits. Therefore, we herein aimed to investigate recent fluid manipulation technologies utilized in paper-based devices and to introduce various approaches adopting several principles to control fluids on papers. Fluid manipulation technologies are classified into passive and active methods. While passive valves are structurally simple and easy to fabricate, they are difficult to control in terms of flow at a specific spatiotemporal condition. On the contrary, active valves are more complicated and mostly require external systems, but they provide much freedom of fluid manipulation and programmable operation. Both technologies have been revolutionized in the way to compensate for their limitations, and their advances will lead to improved performance of μPADs, increasing the level of healthcare around the world.

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Section: Dissolvable Materials (Sucrose) Fluid Velocity Controlmentioning

confidence: 99%

Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

Kim¹,

Hahn

Kim

2020

Micromachines

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“…The reproducibility is similar to those obtained in a previous study using a sugar barrier. 8 The surface topography of the microgrooved channel (N = 10) was examined by field-emission scanning electron microscopy (FE-SEM; JSM-6700FZ, JEOL) and digital microscopy (VHX-5000, Keyence). Figures 4(c) and 4(d) show SEM images and a 3D profile of the grooved surface (N = 10).…”

Section: Flow Rate Measurementmentioning

confidence: 99%

“…Since paper was introduced as a fluidic control device 1 for biochemical assays, paper-based fluidic devices [2][3][4][5][6][7][8][9][10][11] have been developed as a new diagnostic platform and fluid flow control technique because such systems require no external power or off-chip components and include no moving parts.…”

Section: Introductionmentioning

confidence: 99%

“…12 The flow rate of a fluid through the paper channel is proportional to the channel's cross-sectional area, length, and permeability and to the fluid's viscosity. Several researchers have attempted to change the permeability 8,[13][14][15][16] of paper to control the fluid flow. In particular, Chu et al 8 and Lutz et al 14 demonstrated lateral flow control by changing the permeability via infiltration of sugars into paper strips.…”

Section: Introductionmentioning

confidence: 99%

“…Several researchers have attempted to change the permeability 8,[13][14][15][16] of paper to control the fluid flow. In particular, Chu et al 8 and Lutz et al 14 demonstrated lateral flow control by changing the permeability via infiltration of sugars into paper strips. The applicability of these methods to paper channels is limited in terms of device size and sample consumption because of the devices' manufacturing procedure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Paper-like Surface Microstructure Fabricated on a Polymer Surface by Femtosecond Laser Machining

Goya

Fuchiwaki

2018

ANAL. SCI.

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Experimental Laser fabrication systemFigures 1(a) and 1(b) show schematics of the experimental setup and method, respectively, used to fabricate microgrooves 2018 © The Japan Society for Analytical Chemistry † To whom correspondence should be addressed. E-mail: gouya-k@ile.osaka-u.ac.jp K. G. present address: Institute of Laser Engineering, Osaka University, Room 330, Bldg. I, 2-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Paper-like Surface Microstructure Fabricated on a Polymer Surface by Femtosecond Laser MachiningKenji GOYA † and Yusuke FUCHIWAKI Health Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashi, Takamatsu, Kagawa 761-0395, Japan In this study, we demonstrate the precise control of fluid flow using femtosecond (FS) laser-induced microstructures. A microgroove structure inscribed on a poly(methyl methacrylate) (PMMA) substrate functions as a superhydrophilic membrane similar to paper. We first estimated the flow rate for pure water on microgrooves fabricated at various laser fluences in the range from 9.2 to 100.8 J/cm 2 . The results showed that the flow rate could be tuned in the range from 0.30 to 12.07 μL/s by varying the laser irradiation parameters. The fluid flow was reproducible, with a calculated relative standard deviation (RSD%) of less than 8% in the flow rate. We then fabricated a microfilter for blood separation and estimated its filtration ability using artificial blood containing resin microparticles. This method would be useful in a technology related to a paper-based diagnostic device for precise reagent manipulation.

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In situ growth of electroactive polymers via ATRP to construct a biosensing interface for tumor marker

Wang

Han

et al. 2021

Microchim Acta

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Paper-based chemiluminescence immunodevice with temporal controls of reagent transport technique

Cited by 46 publications

References 51 publications

Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

Paper-like Surface Microstructure Fabricated on a Polymer Surface by Femtosecond Laser Machining

In situ growth of electroactive polymers via ATRP to construct a biosensing interface for tumor marker

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