Paper-based electrochemical immunosensor device via Ni-Co MOF nanosheet as a peroxidase mimic for the label-free detection of alpha-fetoprotein

Shu, Yun; Song, Tong; Lu, Qin; Shang, Zhenjiao; Feng, Jianzhou; Jin, Dayong; Zhu, Ai‐Min; Xu, Qin; Hu, Xiaoyun

doi:10.1016/j.snb.2022.132736

Cited by 23 publications

(6 citation statements)

References 39 publications

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“…Moreover, surface chemical modifications can provide a “grip” for anchoring biomolecules and contribute to the binding stability between protein molecules and sensitive films. (iii) Certain catalytic nanomaterials, such as noble metal nanoparticles and nanoenzymes 32 , 33 , are useful for molecular recognition and signal amplification.…”

Section: Electrochemical Protein Biosensorsmentioning

confidence: 99%

“…Nanoenzymes can be defined as nanomaterials with enzymatic properties 53 , combining the excellent properties of nanomaterials with biocatalytic functions, and have received increasing attention in the field of biosensors. Shu et al 32 used Ni-Co MOF nanosheets as a nanoenzyme and modified the surface of graphene nanosheets/polyethylene terephthalate electrodes with this nanoenzyme and CNTs for the detection of AFP. The Ni-Co MOF nanosheets had a high specific surface area and could effectively bind the biotin antibody of AFP.…”

Section: Electrochemical Protein Biosensorsmentioning

confidence: 99%

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Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors. In this review, we summarize recent reports of electrochemical biosensors for protein biomarker detection. We highlight the latest research on electrochemical protein biosensors for the detection of cancer, viral infectious diseases, inflammation, and other diseases. The corresponding sensitive materials, transducer structures, and detection principles associated with such biosensors are also addressed generally. Finally, we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

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Section: Electrochemical Protein Biosensorsmentioning

confidence: 99%

Section: Electrochemical Protein Biosensorsmentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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“…Nowadays, paper-based sensors have been developed in bioanalytical applications [14,15]. Due to this fact that the cellulose papers are cheap, light, available, biodegradable, and easily assembled, a series of POCT based on the paper-based devices have been developed for colorimetric [16], uorescence [17], and electrochemiluminescence [18] techniques.…”

Section: Introductionmentioning

confidence: 99%

Flexible electrochemical paper-based device for detection of breast cancer-derived exosome using nickel nanofoam 3D nanocomposite

Sahraei,

Mazloum-Ardakani,

Moradi

et al. 2024

J Appl Electrochem

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Exosomes as new biomarkers for cancer diagnosis have attracted attention because they are highly released by tumor cells in various biological uids. In this study, an electrochemical paper-based immunosensor device (Exo-sensing paper) is introduced for the detection of exosome in the serum. The Exo-sensing paper is a three electrode system that is prepared using pattern paper and carbon and silver inks. The sensor part of this immunosensor contains a three-dimensional porous nanocomposite of nickel nanofoam coupled with graphene oxide and gold nanoparticles. The high speci c surface area of this nanocomposite increases the antibody loading on the sensor surface signi cantly and consequently leads to obtaining a wide linear range of 500-1 × 10 7 Exospore/µL with a detection limit of 110 Exosome/µL. Due to some advantages of this constructed Exo-sensing paper such as easy storage, simple application, low cost and good selectivity in the real samples, this system has a good potential to be used as a point of care testing for in situ detection of the exosomes and is a promising strategy for minimally invasive liquid biopsy.

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“…Furthermore, this kind of POCT device mainly depends on visual identification and is unable to achieve accurate quantitative measurement of targets owing to its low sensitivity. 15 At the same time, electrochemistrybased POCT devices have gained great attention because of their several advantages, including high sensitivity, low cost, rapid response and easy operation. 16,17 For example, Chen et al reported an integrated flexible electrode for the rapid detection of cancer-related RNA in human urine samples with excellent sensitivity and stability.…”

Section: Introductionmentioning

confidence: 99%

A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

Liu¹,

Ye²,

Chen³

et al. 2023

Analyst

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Paper-based electrochemical immunosensor device via Ni-Co MOF nanosheet as a peroxidase mimic for the label-free detection of alpha-fetoprotein

Cited by 23 publications

References 39 publications

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Flexible electrochemical paper-based device for detection of breast cancer-derived exosome using nickel nanofoam 3D nanocomposite

A bimetallic metal–organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen

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