Paper‐Based Inkjet‐Printed Microfluidic Analytical Devices

Abstract

Rapid, precise, and reproducible deposition of a broad variety of functional materials, including analytical assay reagents and biomolecules, has made inkjet printing an effective tool for the fabrication of microanalytical devices. A ubiquitous office device as simple as a standard desktop printer with its multiple ink cartridges can be used for this purpose. This Review discusses the combination of inkjet printing technology with paper as a printing substrate for the fabrication of microfluidic paper-based analytical devices (μPADs), which have developed into a fast-growing new field in analytical chemistry. After introducing the fundamentals of μPADs and inkjet printing, it touches on topics such as the microfluidic patterning of paper, tailored arrangement of materials, and functionalities achievable exclusively by the inkjet deposition of analytical assay components, before concluding with an outlook on future perspectives.

Microfluidic Paper-based Analytical Device for the Determination of Hexavalent Chromium by Photolithographic Fabrication Using a Photomask Printed with 3D Printer

“…Recently, microfluidic paper-based analytical devices (μPADs) have attracted a lot of attention and have been actively developed due to being simple, inexpensive, user-friendly, and disposable. [12][13][14][15][16] To date, μPADs have been used as elegant analytical tools for a variety of applications, including medical diagnosis, [17][18][19][20][21] food testing, 22 and environmental monitoring. [23][24][25][26][27][28][29] A lot of detection methods have been used for μPADs.…”

Microfluidic Paper-based Analytical Device for Quantification of Lead Using Reaction Band-length for Identification of Bullet Hole and Its Potential for Estimating Firing Distance

“…The hydrophobic barrier constrains the liquid within the flow channel and guides the liquid flow in a controllable manner. [13][14][15] There are several techniques for quantitative analysis on μPADs. [16][17][18][19][20][21][22] The most common detection mode is colorimetric detection using specific reagents to quantify the analyte using its color intensity.…”

Practical High-Performance Lateral Flow Assay Based on Autonomous Microfluidic Replacement on a Film

“…Among POCT devices, paper-based devices have been seen as the ideal platform for point-of-care (POC) diagnostics due to their very low cost, simplicity, and inherent ability to wick fluids. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Fluid transport eliminates expensive pumping instrumentation and complicated handling. 16,17 The porous structure of paper is very convenient for dot-immunobinding assays, and cellulose itself has high affinity to biomolecules.…”