Paper-Based Molecular-Imprinting Technology and Its Application

Xu, Shufang; Xu, Zhefeng; Liu, Zhimin

doi:10.3390/bios12080595

Cited by 22 publications

(6 citation statements)

References 95 publications

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“…At this moment, the corresponding coal sample can be called a representative element volume. Therefore, by controlling the volume of the model near the representative element volume, it can not only ensure that the model can better represent the whole coal sample but also reduce the burden and calculation time of the computer . As shown in Figure , the side length of the unit body is in the range of 350–550 pixels, and the total porosity has been on the rise.…”

Section: Construction Of the Microscopic Pore Fracture Structure Mode...mentioning

confidence: 99%

Scale Effect of Coal Porosity and Permeability Characteristics Based on CT 3D Reconstruction from a Microperspective

Fan,

Jiang,

Fan

et al. 2024

Energy Fuels

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In order to explore the impact of the scale effect on the coal seepage from a microscopic perspective, CT scanning experiments were carried out on coal samples selected from the Zhangcun Coal Mine in Shanxi Province. The scanned images were processed by means of the Avizo software, and the real pore fracture model of coal samples was established through the three-dimensional reconstruction technology. Based on the qualitative characterization of pores and fissures in the model, the microstructure of pores and fissures in coal is analyzed. The influence of the scale effect on the porosity and permeability characteristics of a coal seam is discussed by numerical simulation of the representative pores and fissures. The results show that the fractures in the coal sample are developed and have strong connectivity. 87% of the fractures are longer than 5000 μm and wider than 1000 μm. The permeability of coal samples is between 0.079 and 0.298 mD. With the increase of the scale of coal samples, the change process of the permeability can be divided into three stages: gradually increasing, slowly decreasing, and keeping steady. From the microscopic perspective, the porosity and permeability of coal samples are in accord with the cubic function relationship.

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Section: Construction Of the Microscopic Pore Fracture Structure Mode...mentioning

confidence: 99%

Scale Effect of Coal Porosity and Permeability Characteristics Based on CT 3D Reconstruction from a Microperspective

Fan,

Jiang,

Fan

et al. 2024

Energy Fuels

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“…The precision and dependability of biosensing data can be impacted by sample preparation and matrix effects. 160 Certain biomimetic receptors, such as aptamers, are susceptible to changes in pH and temperature in the environment. It can be difficult to guarantee their stability when being stored and used, especially for biosensors that can be deployed in the field.…”

Section: Applications Of Aptamers and Biomimetic Receptors In Biosensingmentioning

confidence: 99%

Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Tripathi,

Pandey,

Mishra

et al. 2024

J. Electrochem. Soc.

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The fields of biosensing have been transformed by the discovery of extraordinary molecular recognition components, such as aptamers and biomimetic receptors. Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is a method used to select aptamers, or short sequences of single-stranded DNA (ssDNA) or RNA (ssRNA), based on their unique binding affinity to target molecules. Molecularly imprinted polymers (MIPs) are a type of biomimetic receptor that mimics the selectivity of natural receptors inside a synthetic matrix. They make it possible to identify pathogens, and illness biomarkers with accuracy. Aptamers and biomimetic receptors play crucial roles in various fields including diagnostics, therapeutics, and biosensing. Their high specificity, versatility, and adaptability enable targeted detection, drug delivery, and biomolecule manipulation, thereby contributing to advancements in personalized medicine, biotechnology, and disease diagnosis. Aptamers and biomimetic receptors have been combined with cutting-edge technologies, like nanotechnology and lab-on-a-chip systems, to create biosensors that are quick, portable, and extremely sensitive. These recognition features are anticipated to become more important as technology develops, helping to address global issues, advance biosensing capabilities, and raise people's standard of living everywhere. Recent advancements and innovation on Aptamers and Biomimetic Receptors in Biosensing have been discussed in this review article.

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“…MIPs are most commonly used in sample preparation of small molecules, but also MIPs for selective enrichment of proteins are described 27 . Several MIPs, including MIPs targeting proteins, have been imprinted on paper 28 . These are used mainly used in sensing systems, e.g., MIPs for chymotrypsinogen determination in urine using a distance detection‐based microfluidic paper 29 and a fluorescent MIP for ferritin determination 30 .…”

Section: Reshuffling the Workflow In Mass Spectrometric Protein Analy...mentioning

confidence: 99%

“… 27 Several MIPs, including MIPs targeting proteins, have been imprinted on paper. 28 These are used mainly used in sensing systems, e.g., MIPs for chymotrypsinogen determination in urine using a distance detection‐based microfluidic paper 29 and a fluorescent MIP for ferritin determination. 30 However, MIPs for the capture of small molecules (metabolites) from urine have been polymerized on paper for analysis by paper spray MS. 31 Hence, the production of MIPs on paper for protein analysis by MS should also be feasible.…”

Section: Reshuffling the Workflow In Mass Spectrometric Protein Analy...mentioning

confidence: 99%

Is this the end of dried blood spots as we know it?

Halvorsen

Reubsaet

2023

Analytical Science Advances

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In 2017 integrated sampling and sample preparation for simplified liquid chromatography‐mass spectrometry analysis of proteins from dried blood spots were introduced. The concept, called smart samplers or smart sampling, enables proteolysis or affinity clean‐up, two common sample preparation steps in liquid chromatography‐mass spectrometric bioanalysis of proteins, to start at the moment of sampling. The idea is to utilize the time for sampling and drying to perform these time‐consuming and labour‐intensive steps. Hence, only a simplified sample preparation is necessary after the arrival of the sample in the lab. In this perspective, we present an overview of the smart sampling approach where the conventional protein analysis workflow is reshuffled to start already prior to arrival in the lab. In addition, we present a thorough discussion of integrating sample preparation steps such as proteolysis or affinity capture in the sampling. Finally, in the end, we try to answer the question if conventional dried blood spots will become obsolete in the future.

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Paper-Based Molecular-Imprinting Technology and Its Application

Cited by 22 publications

References 95 publications

Scale Effect of Coal Porosity and Permeability Characteristics Based on CT 3D Reconstruction from a Microperspective

Scale Effect of Coal Porosity and Permeability Characteristics Based on CT 3D Reconstruction from a Microperspective

Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications

Is this the end of dried blood spots as we know it?

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